Molecular basis of NK cell recognition and function

• Pubblicazione: [Place of publication not identified], : Karger, 1996
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (XII + 184 pages) : : 25 figures, 19 tables
• Soggetto topico: Lymphocytes; Leukocytes, Mononuclear; Leukocytes; Blood Cells; Immune System; Cells; Blood; Hemic and Immune Systems; Anatomy; Killer Cells, Natural
• Persona (resp. second.): MorettaLorenzo
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di contenuto: CIA199606400I -- CIA19960640XI.PDF.pdf -- CIA1996064001 -- CIA1996064019 -- CIA1996064028 -- CIA1996064044 -- CIA1996064059 -- CIA1996064077 -- CIA1996064088 -- CIA1996064104 -- CIA1996064116 -- CIA1996064135 -- CIA1996064146 -- CIA1996064164 -- CIA1996064181.
• Sommario/riassunto: Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists.
• Titolo autorizzato: Molecular basis of NK cell recognition and function
• ISBN: 9783318015515; 3318015512
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910155287503321
• Lo trovi qui: Univ. Federico II
• Serie: Issn Series