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[null,"1.","Record Nr.",null,"UNINA9910155287503321"]
[null,null,"Titolo",null,"Molecular basis of NK cell recognition and function"]
[null,null,"Pubbl/distr/stampa",null,"[Place of publication not identified], : Karger, 1996"]
[null,null,"ISBN",null,"9783318015515"]
[{"$nulls":4},"3318015512"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XII + 184 pages) : :   25 figures, 19 tables"]
[null,null,"Collana",null,"Issn Series"]
[null,null,"Soggetti",null,"Lymphocytes"]
[{"$nulls":4},"Leukocytes, Mononuclear"]
[{"$nulls":4},"Leukocytes"]
[{"$nulls":4},"Blood Cells"]
[{"$nulls":4},"Immune System"]
[{"$nulls":4},"Cells"]
[{"$nulls":4},"Blood"]
[{"$nulls":4},"Hemic and Immune Systems"]
[{"$nulls":4},"Anatomy"]
[{"$nulls":4},"Killer Cells, Natural"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"CIA199606400I -- CIA19960640XI.PDF.pdf -- CIA1996064001 -- CIA1996064019 -- CIA1996064028 -- CIA1996064044 -- CIA1996064059 -- CIA1996064077 -- CIA1996064088 -- CIA1996064104 -- CIA1996064116 -- CIA1996064135 -- CIA1996064146 -- CIA1996064164 -- CIA1996064181."]
[null,null,null,"Sommario/riassunto","Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these "]
[{"$nulls":4},"receptors in the negative control of T cell responses.  This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists."]