LEADER 03467nam 2200721zu 450 001 9910155287503321 005 20210803234306.0 010 $a9783318015515 010 $a3318015512 035 $a(CKB)3780000000101761 035 $a(SSID)ssj0000578688 035 $a(PQKBManifestationID)12227348 035 $a(PQKBTitleCode)TC0000578688 035 $a(PQKBWorkID)10578849 035 $a(PQKB)10602726 035 $a(OCoLC)849652564 035 $a(SZ-BaSKA)223049 035 $a(MiAaPQ)EBC31866872 035 $a(Au-PeEL)EBL31866872 035 $a(EXLCZ)993780000000101761 100 $a20160829d1996 uy 101 0 $aeng 135 $aurunu||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular basis of NK cell recognition and function 205 $a1st ed. 210 31$a[Place of publication not identified]$cKarger$d1996 215 $a1 online resource (XII + 184 pages) : $c 25 figures, 19 tables 225 1 $aIssn Series 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9783805563321 311 08$a3805563329 327 $aCIA199606400I -- CIA19960640XI.PDF.pdf -- CIA1996064001 -- CIA1996064019 -- CIA1996064028 -- CIA1996064044 -- CIA1996064059 -- CIA1996064077 -- CIA1996064088 -- CIA1996064104 -- CIA1996064116 -- CIA1996064135 -- CIA1996064146 -- CIA1996064164 -- CIA1996064181. 330 $aNatural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists. 410 0$aIssn Series 606 $aLymphocytes 606 $aLeukocytes, Mononuclear 606 $aLeukocytes 606 $aBlood Cells 606 $aImmune System 606 $aCells 606 $aBlood 606 $aHemic and Immune Systems 606 $aAnatomy 606 $aKiller Cells, Natural 615 2$aLymphocytes 615 2$aLeukocytes, Mononuclear 615 2$aLeukocytes 615 2$aBlood Cells 615 2$aImmune System 615 2$aCells 615 2$aBlood 615 2$aHemic and Immune Systems 615 2$aAnatomy 615 2$aKiller Cells, Natural 702 $aMoretta$b Lorenzo 801 0$bPQKB 906 $aBOOK 912 $a9910155287503321 996 $aMolecular basis of NK cell recognition and function$92788854 997 $aUNINA