03467nam 2200721zu 450 991015528750332120210803234306.097833180155153318015512(CKB)3780000000101761(SSID)ssj0000578688(PQKBManifestationID)12227348(PQKBTitleCode)TC0000578688(PQKBWorkID)10578849(PQKB)10602726(OCoLC)849652564(SZ-BaSKA)223049(MiAaPQ)EBC31866872(Au-PeEL)EBL31866872(EXLCZ)99378000000010176120160829d1996 uy engurunu|||||txtccrMolecular basis of NK cell recognition and function1st ed.[Place of publication not identified]Karger19961 online resource (XII + 184 pages) : 25 figures, 19 tablesIssn SeriesBibliographic Level Mode of Issuance: Monograph9783805563321 3805563329 CIA199606400I -- CIA19960640XI.PDF.pdf -- CIA1996064001 -- CIA1996064019 -- CIA1996064028 -- CIA1996064044 -- CIA1996064059 -- CIA1996064077 -- CIA1996064088 -- CIA1996064104 -- CIA1996064116 -- CIA1996064135 -- CIA1996064146 -- CIA1996064164 -- CIA1996064181.Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists.Issn SeriesLymphocytesLeukocytes, MononuclearLeukocytesBlood CellsImmune SystemCellsBloodHemic and Immune SystemsAnatomyKiller Cells, NaturalLymphocytesLeukocytes, MononuclearLeukocytesBlood CellsImmune SystemCellsBloodHemic and Immune SystemsAnatomyKiller Cells, NaturalMoretta LorenzoPQKBBOOK9910155287503321Molecular basis of NK cell recognition and function2788854UNINA