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Record Nr. |
UNINA9910155287503321 |
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Titolo |
Molecular basis of NK cell recognition and function |
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Pubbl/distr/stampa |
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[Place of publication not identified], : Karger, 1996 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (XII + 184 pages) : : 25 figures, 19 tables |
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Collana |
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Soggetti |
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Lymphocytes |
Leukocytes, Mononuclear |
Leukocytes |
Blood Cells |
Immune System |
Cells |
Blood |
Hemic and Immune Systems |
Anatomy |
Killer Cells, Natural |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di contenuto |
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CIA199606400I -- CIA19960640XI.PDF.pdf -- CIA1996064001 -- CIA1996064019 -- CIA1996064028 -- CIA1996064044 -- CIA1996064059 -- CIA1996064077 -- CIA1996064088 -- CIA1996064104 -- CIA1996064116 -- CIA1996064135 -- CIA1996064146 -- CIA1996064164 -- CIA1996064181. |
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Sommario/riassunto |
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Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. |
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Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists. |
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