Health effects of ingested fluoride / / Subcommittee on Health Effects of Ingested Fluoride, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council

• Pubblicazione: Washington, D.C., : National Academy Press, 1993
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (197 p.)
• Disciplina: 615.9/257312
• Soggetto topico: Fluorides - Toxicology; Fluorides - Metabolism; Fluorides - Physiological effect; Water - Fluoridation - Health aspects
• Altri autori: WagnerBernard Meyer <1928->
• Note generali: Project was supported by the U.S. Environmental Protection Agency under contract CR-819504-01-0.; Subcommittee chairman: Bernard M. Wagner.
• Nota di bibliografia: Includes bibliographical references (p. 135-166).
• Nota di contenuto: Health Effects of Ingested Fluoride -- Copyright -- Preface -- Contents -- Health Effects of Ingested Fluoride -- Executive Summary -- INTRODUCTION -- INTAKE, METABOLISM, AND DISPOSITION OF FLUORIDE -- DENTAL FLUOROSIS -- FLUORIDE AND BONE FRACTURES -- EFFECTS OF FLUORIDE ON THE RENAL SYSTEM -- EFFECTS OF FLUORIDE ON THE GASTROINTESTINAL SYSTEM -- EFFECTS OF FLUORIDE ON HYPERSENSITIVITY AND THE IMMUNE SYSTEM -- EFFECTS OF FLUORIDE ON REPRODUCTION -- GENOTOXICITY -- CARCINOGENICITY -- CONCLUSIONS -- Health Effects of Ingested Fluoride -- 1 Introduction -- 2 Dental Fluorosis -- THE FLUORIDE CONTENT OF TEETH -- FLUORIDE'S ACTION IN PREVENTING DENTAL CARIES -- HISTOPATHOLOGY OF DENTAL FLUOROSIS -- DIAGNOSTIC ISSUES IN DENTAL FLUOROSIS -- INDEXES FOR DENTAL FLUOROSIS -- DENTAL FLUOROSIS AND FLUORIDE INTAKE -- PREVALENCE OF DENTAL FLUOROSIS -- RISK FACTORS IN DENTAL FLUOROSIS -- THE RELATION BETWEEN DENTAL FLUOROSIS AND CARIES -- CONCLUSIONS -- RESEARCH RECOMMENDATIONS -- 3 Fluoride Exposure and Risk of Bone Fracture -- BONE FRACTURE IN HUMANS -- Clinical Trials of Fluoride -- Population Studies -- Studies Using Information from Individuals -- Studies Using Population Characteristics -- Skeletal Fluorosis -- Discussion -- BONE FRACTURE IN ANIMALS -- Discussion -- 4 Reproductive Effects of Fluoride -- REPRODUCTIVE EFFECTS IN HUMANS -- REPRODUCTIVE EFFECTS IN ANIMALS -- DISCUSSION -- 5 Effects of Ingested Fluoride on Renal, Gastrointestinal, and Immune Systems -- EFFECTS ON THE RENAL SYSTEM -- EFFECTS ON THE GASTROINTESTINAL SYSTEM -- HYPERSENSITIVITY AND IMMUNOLOGICAL EFFECTS -- DISCUSSION -- 6 Genotoxicity of Fluoride -- IN VITRO GENOTOXICITY TEST SYSTEMS -- Microbes -- Mammalian Cells -- Gene Mutations -- Chromosomal Aberrations and Sister Chromatid Exchanges -- Animal Cells -- Human Cells -- DNA Damage and Repair -- Transformation -- Discussion. ; IN VIVO GENOTOXICITY TEST SYSTEMS -- Drosophila -- Rodents -- Somatic Cells -- Germ Cells -- Human Studies -- PROPOSED MECHANISMS OF GENOTOXICITY -- SUMMARY -- 7 Carcinogenicity of Fluoride -- FLUORIDE CARCINOGENCITY IN HUMANS -- FLUORIDE CARCINOGENICITY IN ANIMALS -- Early Toxicological Studies Of Fluoride and Cancer -- Recent Carcinogenicity Bioassays -- CONCLUSIONS -- RECOMMENDATIONS -- 8 Intake, Metabolism, and Disposition of Fluoride -- FLUORIDE INTAKE -- FLUORIDE ABSORPTION -- FLUORIDE IN PLASMA -- TISSUE DISTRIBUTION -- FLUORIDE EXCRETION -- RECOMMENDATIONS -- References -- Appendix 1 Criteria for Dean's Index, TF Index, and TSIF -- Appendix 2 Letter to AFIP -- Appendix 3 AFIP Response.
• Sommario/riassunto: This book reviews the effects on health of fluoride ingested from various sources. Those health effects reviewed include dental fluorosis; bone fracture; effects on renal, reproductive, and gastrointestinal systems; and genotoxicity and carcinogenicity. The book also reviews the Environmental Protection Agency's current drinking-water standard for fluoride and considers future research needs.
• Titolo autorizzato: Health effects of ingested fluoride
• ISBN: 9786610211333; 9781280211331; 1280211334; 9780309596381; 0309596386; 9780585028729; 0585028729
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910970035703321
• Lo trovi qui: Univ. Federico II