05527nam 2200769 a 450 991097003570332120251116141228.09786610211333978128021133112802113349780309596381030959638697805850287290585028729(CKB)110986584753402(OCoLC)42329401(CaPaEBR)ebrary10057060(SSID)ssj0000169502(PQKBManifestationID)11164020(PQKBTitleCode)TC0000169502(PQKBWorkID)10203503(PQKB)11151257(MiAaPQ)EBC3376782(Au-PeEL)EBL3376782(CaPaEBR)ebr10057060(CaONFJC)MIL21133(OCoLC)814277663(Perlego)4739918(BIP)703764(EXLCZ)9911098658475340219931022d1993 uy 0engurcn|||||||||txtccrHealth effects of ingested fluoride /Subcommittee on Health Effects of Ingested Fluoride, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council1st ed.Washington, D.C. National Academy Press19931 online resource (197 p.) Project was supported by the U.S. Environmental Protection Agency under contract CR-819504-01-0.Subcommittee chairman: Bernard M. Wagner.9780309049757 030904975X Includes bibliographical references (p. 135-166).Health Effects of Ingested Fluoride -- Copyright -- Preface -- Contents -- Health Effects of Ingested Fluoride -- Executive Summary -- INTRODUCTION -- INTAKE, METABOLISM, AND DISPOSITION OF FLUORIDE -- DENTAL FLUOROSIS -- FLUORIDE AND BONE FRACTURES -- EFFECTS OF FLUORIDE ON THE RENAL SYSTEM -- EFFECTS OF FLUORIDE ON THE GASTROINTESTINAL SYSTEM -- EFFECTS OF FLUORIDE ON HYPERSENSITIVITY AND THE IMMUNE SYSTEM -- EFFECTS OF FLUORIDE ON REPRODUCTION -- GENOTOXICITY -- CARCINOGENICITY -- CONCLUSIONS -- Health Effects of Ingested Fluoride -- 1 Introduction -- 2 Dental Fluorosis -- THE FLUORIDE CONTENT OF TEETH -- FLUORIDE'S ACTION IN PREVENTING DENTAL CARIES -- HISTOPATHOLOGY OF DENTAL FLUOROSIS -- DIAGNOSTIC ISSUES IN DENTAL FLUOROSIS -- INDEXES FOR DENTAL FLUOROSIS -- DENTAL FLUOROSIS AND FLUORIDE INTAKE -- PREVALENCE OF DENTAL FLUOROSIS -- RISK FACTORS IN DENTAL FLUOROSIS -- THE RELATION BETWEEN DENTAL FLUOROSIS AND CARIES -- CONCLUSIONS -- RESEARCH RECOMMENDATIONS -- 3 Fluoride Exposure and Risk of Bone Fracture -- BONE FRACTURE IN HUMANS -- Clinical Trials of Fluoride -- Population Studies -- Studies Using Information from Individuals -- Studies Using Population Characteristics -- Skeletal Fluorosis -- Discussion -- BONE FRACTURE IN ANIMALS -- Discussion -- 4 Reproductive Effects of Fluoride -- REPRODUCTIVE EFFECTS IN HUMANS -- REPRODUCTIVE EFFECTS IN ANIMALS -- DISCUSSION -- 5 Effects of Ingested Fluoride on Renal, Gastrointestinal, and Immune Systems -- EFFECTS ON THE RENAL SYSTEM -- EFFECTS ON THE GASTROINTESTINAL SYSTEM -- HYPERSENSITIVITY AND IMMUNOLOGICAL EFFECTS -- DISCUSSION -- 6 Genotoxicity of Fluoride -- IN VITRO GENOTOXICITY TEST SYSTEMS -- Microbes -- Mammalian Cells -- Gene Mutations -- Chromosomal Aberrations and Sister Chromatid Exchanges -- Animal Cells -- Human Cells -- DNA Damage and Repair -- Transformation -- Discussion.IN VIVO GENOTOXICITY TEST SYSTEMS -- Drosophila -- Rodents -- Somatic Cells -- Germ Cells -- Human Studies -- PROPOSED MECHANISMS OF GENOTOXICITY -- SUMMARY -- 7 Carcinogenicity of Fluoride -- FLUORIDE CARCINOGENCITY IN HUMANS -- FLUORIDE CARCINOGENICITY IN ANIMALS -- Early Toxicological Studies Of Fluoride and Cancer -- Recent Carcinogenicity Bioassays -- CONCLUSIONS -- RECOMMENDATIONS -- 8 Intake, Metabolism, and Disposition of Fluoride -- FLUORIDE INTAKE -- FLUORIDE ABSORPTION -- FLUORIDE IN PLASMA -- TISSUE DISTRIBUTION -- FLUORIDE EXCRETION -- RECOMMENDATIONS -- References -- Appendix 1 Criteria for Dean's Index, TF Index, and TSIF -- Appendix 2 Letter to AFIP -- Appendix 3 AFIP Response.This book reviews the effects on health of fluoride ingested from various sources. Those health effects reviewed include dental fluorosis; bone fracture; effects on renal, reproductive, and gastrointestinal systems; and genotoxicity and carcinogenicity. The book also reviews the Environmental Protection Agency's current drinking-water standard for fluoride and considers future research needs.FluoridesToxicologyFluoridesMetabolismFluoridesPhysiological effectWaterFluoridationHealth aspectsFluoridesToxicology.FluoridesMetabolism.FluoridesPhysiological effect.WaterFluoridationHealth aspects.615.9/257312Wagner Bernard Meyer1928-508304National Research Council (U.S.).Board on Environmental Studies and Toxicology.National Research Council (U.S.).Commission on Life Sciences.MiAaPQMiAaPQMiAaPQBOOK9910970035703321Health effects of ingested fluoride4368431UNINA