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[null,"1.","Record Nr.",null,"UNINA9910970035703321"]
[null,null,"Titolo",null,"Health effects of ingested fluoride / / Subcommittee on Health Effects of Ingested Fluoride, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council"]
[null,null,"Pubbl/distr/stampa",null,"Washington, D.C., : National Academy Press, 1993"]
[null,null,"ISBN",null,"9786610211333"]
[{"$nulls":4},"9781280211331"]
[{"$nulls":4},"1280211334"]
[{"$nulls":4},"9780309596381"]
[{"$nulls":4},"0309596386"]
[{"$nulls":4},"9780585028729"]
[{"$nulls":4},"0585028729"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (197 p.)"]
[null,null,"Disciplina",null,"615.9/257312"]
[null,null,"Soggetti",null,"Fluorides - Toxicology"]
[{"$nulls":4},"Fluorides - Metabolism"]
[{"$nulls":4},"Fluorides - Physiological effect"]
[{"$nulls":4},"Water - Fluoridation - Health aspects"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Project was supported by the U.S. Environmental Protection Agency under contract CR-819504-01-0."]
[{"$nulls":4},"Subcommittee chairman: Bernard M. Wagner."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 135-166)."]
[null,null,"Nota di contenuto",null,"Health Effects of Ingested Fluoride -- Copyright -- Preface -- Contents -- Health Effects of Ingested Fluoride -- Executive Summary -- INTRODUCTION -- INTAKE, METABOLISM, AND DISPOSITION OF FLUORIDE -- DENTAL FLUOROSIS -- FLUORIDE AND BONE FRACTURES -- EFFECTS OF FLUORIDE ON THE RENAL SYSTEM -- EFFECTS OF FLUORIDE ON THE GASTROINTESTINAL SYSTEM -- EFFECTS OF FLUORIDE ON HYPERSENSITIVITY AND THE IMMUNE SYSTEM -- EFFECTS OF FLUORIDE ON REPRODUCTION -- GENOTOXICITY -- CARCINOGENICITY -- CONCLUSIONS -- Health Effects of Ingested Fluoride -- 1 Introduction -- 2 Dental Fluorosis -- THE FLUORIDE CONTENT OF TEETH -- FLUORIDE'S ACTION IN PREVENTING DENTAL CARIES -- HISTOPATHOLOGY OF DENTAL FLUOROSIS -- DIAGNOSTIC "]
[{"$nulls":4},"ISSUES IN DENTAL FLUOROSIS -- INDEXES FOR DENTAL FLUOROSIS -- DENTAL FLUOROSIS AND FLUORIDE INTAKE -- PREVALENCE OF DENTAL FLUOROSIS -- RISK FACTORS IN DENTAL FLUOROSIS -- THE RELATION BETWEEN DENTAL FLUOROSIS AND CARIES -- CONCLUSIONS -- RESEARCH RECOMMENDATIONS -- 3 Fluoride Exposure and Risk of Bone Fracture -- BONE FRACTURE IN HUMANS -- Clinical Trials of Fluoride -- Population Studies -- Studies Using Information from Individuals -- Studies Using Population Characteristics -- Skeletal Fluorosis -- Discussion -- BONE FRACTURE IN ANIMALS -- Discussion -- 4 Reproductive Effects of Fluoride -- REPRODUCTIVE EFFECTS IN HUMANS -- REPRODUCTIVE EFFECTS IN ANIMALS -- DISCUSSION -- 5 Effects of Ingested Fluoride on Renal, Gastrointestinal, and Immune Systems -- EFFECTS ON THE RENAL SYSTEM -- EFFECTS ON THE GASTROINTESTINAL SYSTEM -- HYPERSENSITIVITY AND IMMUNOLOGICAL EFFECTS -- DISCUSSION -- 6 Genotoxicity of Fluoride -- IN VITRO GENOTOXICITY TEST SYSTEMS -- Microbes -- Mammalian Cells -- Gene Mutations -- Chromosomal Aberrations and Sister Chromatid Exchanges -- Animal Cells -- Human Cells -- DNA Damage and Repair -- Transformation -- Discussion."]
[{"$nulls":4},"IN VIVO GENOTOXICITY TEST SYSTEMS -- Drosophila -- Rodents -- Somatic Cells -- Germ Cells -- Human Studies -- PROPOSED MECHANISMS OF GENOTOXICITY -- SUMMARY -- 7 Carcinogenicity of Fluoride -- FLUORIDE CARCINOGENCITY IN HUMANS -- FLUORIDE CARCINOGENICITY IN ANIMALS -- Early Toxicological Studies Of Fluoride and Cancer -- Recent Carcinogenicity Bioassays -- CONCLUSIONS -- RECOMMENDATIONS -- 8 Intake, Metabolism, and Disposition of Fluoride -- FLUORIDE INTAKE -- FLUORIDE ABSORPTION -- FLUORIDE IN PLASMA -- TISSUE DISTRIBUTION -- FLUORIDE EXCRETION -- RECOMMENDATIONS -- References -- Appendix 1 Criteria for Dean's Index, TF Index, and TSIF -- Appendix 2 Letter to AFIP -- Appendix 3 AFIP Response."]
[null,null,null,"Sommario/riassunto","This book reviews the effects on health of fluoride ingested from various sources. Those health effects reviewed include dental fluorosis; bone fracture; effects on renal, reproductive, and gastrointestinal systems; and genotoxicity and carcinogenicity. The book also reviews the Environmental Protection Agency's current drinking-water standard for fluoride and considers future research needs."]