| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910970035703321 |
|
|
Titolo |
Health effects of ingested fluoride / / Subcommittee on Health Effects of Ingested Fluoride, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Washington, D.C., : National Academy Press, 1993 |
|
|
|
|
|
|
|
ISBN |
|
9786610211333 |
9781280211331 |
1280211334 |
9780309596381 |
0309596386 |
9780585028729 |
0585028729 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (197 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
WagnerBernard Meyer <1928-> |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Fluorides - Toxicology |
Fluorides - Metabolism |
Fluorides - Physiological effect |
Water - Fluoridation - Health aspects |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Project was supported by the U.S. Environmental Protection Agency under contract CR-819504-01-0. |
Subcommittee chairman: Bernard M. Wagner. |
|
|
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references (p. 135-166). |
|
|
|
|
|
|
Nota di contenuto |
|
Health Effects of Ingested Fluoride -- Copyright -- Preface -- Contents -- Health Effects of Ingested Fluoride -- Executive Summary -- INTRODUCTION -- INTAKE, METABOLISM, AND DISPOSITION OF FLUORIDE -- DENTAL FLUOROSIS -- FLUORIDE AND BONE FRACTURES -- EFFECTS OF FLUORIDE ON THE RENAL SYSTEM -- EFFECTS OF FLUORIDE ON THE GASTROINTESTINAL SYSTEM -- EFFECTS OF FLUORIDE ON HYPERSENSITIVITY AND THE IMMUNE SYSTEM -- EFFECTS OF FLUORIDE ON REPRODUCTION -- GENOTOXICITY -- CARCINOGENICITY -- CONCLUSIONS -- Health Effects of Ingested Fluoride -- 1 Introduction -- 2 Dental Fluorosis -- THE FLUORIDE |
|
|
|
|
|
|
|
|
|
|
|
CONTENT OF TEETH -- FLUORIDE'S ACTION IN PREVENTING DENTAL CARIES -- HISTOPATHOLOGY OF DENTAL FLUOROSIS -- DIAGNOSTIC ISSUES IN DENTAL FLUOROSIS -- INDEXES FOR DENTAL FLUOROSIS -- DENTAL FLUOROSIS AND FLUORIDE INTAKE -- PREVALENCE OF DENTAL FLUOROSIS -- RISK FACTORS IN DENTAL FLUOROSIS -- THE RELATION BETWEEN DENTAL FLUOROSIS AND CARIES -- CONCLUSIONS -- RESEARCH RECOMMENDATIONS -- 3 Fluoride Exposure and Risk of Bone Fracture -- BONE FRACTURE IN HUMANS -- Clinical Trials of Fluoride -- Population Studies -- Studies Using Information from Individuals -- Studies Using Population Characteristics -- Skeletal Fluorosis -- Discussion -- BONE FRACTURE IN ANIMALS -- Discussion -- 4 Reproductive Effects of Fluoride -- REPRODUCTIVE EFFECTS IN HUMANS -- REPRODUCTIVE EFFECTS IN ANIMALS -- DISCUSSION -- 5 Effects of Ingested Fluoride on Renal, Gastrointestinal, and Immune Systems -- EFFECTS ON THE RENAL SYSTEM -- EFFECTS ON THE GASTROINTESTINAL SYSTEM -- HYPERSENSITIVITY AND IMMUNOLOGICAL EFFECTS -- DISCUSSION -- 6 Genotoxicity of Fluoride -- IN VITRO GENOTOXICITY TEST SYSTEMS -- Microbes -- Mammalian Cells -- Gene Mutations -- Chromosomal Aberrations and Sister Chromatid Exchanges -- Animal Cells -- Human Cells -- DNA Damage and Repair -- Transformation -- Discussion. |
IN VIVO GENOTOXICITY TEST SYSTEMS -- Drosophila -- Rodents -- Somatic Cells -- Germ Cells -- Human Studies -- PROPOSED MECHANISMS OF GENOTOXICITY -- SUMMARY -- 7 Carcinogenicity of Fluoride -- FLUORIDE CARCINOGENCITY IN HUMANS -- FLUORIDE CARCINOGENICITY IN ANIMALS -- Early Toxicological Studies Of Fluoride and Cancer -- Recent Carcinogenicity Bioassays -- CONCLUSIONS -- RECOMMENDATIONS -- 8 Intake, Metabolism, and Disposition of Fluoride -- FLUORIDE INTAKE -- FLUORIDE ABSORPTION -- FLUORIDE IN PLASMA -- TISSUE DISTRIBUTION -- FLUORIDE EXCRETION -- RECOMMENDATIONS -- References -- Appendix 1 Criteria for Dean's Index, TF Index, and TSIF -- Appendix 2 Letter to AFIP -- Appendix 3 AFIP Response. |
|
|
|
|
|
|
Sommario/riassunto |
|
This book reviews the effects on health of fluoride ingested from various sources. Those health effects reviewed include dental fluorosis; bone fracture; effects on renal, reproductive, and gastrointestinal systems; and genotoxicity and carcinogenicity. The book also reviews the Environmental Protection Agency's current drinking-water standard for fluoride and considers future research needs. |
|
|
|
|
|
|
|
| |