Paediatric Formulation: Design and Development

• Autore: Denora Nunzio
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Descrizione fisica: 1 online resource (205 p.)
• Soggetto topico: Medicine
• Soggetto non controllato: acceptable; administration; age-related; anakinra; autoinflammatory disease; bioavailability; biopharmaceutics; canakinumab; child; children; chronic myeloid leukemia; confocal microscopy; cyclodextrin inclusion complex; dasatinib; design; design of experiments; development; device; dosage form; drug delivery; Duchenne muscular dystrophy; edible films; excipient; flavor profile; formulation; formulation development; grinding; imatinib; inhaled; innovative biotechnologies; Interleukin-1; intra nasal; Kawasaki disease; liquid formulation; medication error; modified release; neglected tropical diseases; neonates; NICU; nilotinb; Norvir®; oral; Orodispersible formulation; paediatric; paediatric age; paediatric dosage forms; paediatric formulation development; palatability assessment; palatable; parenteral; pediatric; pediatric age; pediatric drug delivery; pediatrics; penetration; personalized medicine; phase solubility studies; polymorph; ponatinib; poorly soluble compound; poorly water soluble drug; product development; pyrazinamide; retinoblastoma; ritonavir; solubility enhancement; spray congealing; systemic juvenile idiopathic arthritis; taste-masking; topical; topotecan; tuberculosis; tumorspheres; tyrosine kinase inhibitors
• Persona (resp. second.): LopalcoAntonio; DenoraNunzio
• Sommario/riassunto: The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
• Altri titoli varianti: Paediatric Formulation
• Titolo autorizzato: Paediatric Formulation: Design and Development
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557304003321
• Lo trovi qui: Univ. Federico II