04637nam 2201249z- 450 991055730400332120231214133045.0(CKB)5400000000042816(oapen)https://directory.doabooks.org/handle/20.500.12854/76438(EXLCZ)99540000000004281620202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPaediatric Formulation: Design and DevelopmentBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (205 p.)3-0365-0740-X 3-0365-0741-8 The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.Paediatric FormulationMedicinebicsscdasatinibDuchenne muscular dystrophycyclodextrin inclusion complexphase solubility studiespaediatric ageliquid formulationtumorspheresretinoblastomatopotecanpenetrationconfocal microscopypoorly water soluble drugsolubility enhancementgrindingspray congealingneglected tropical diseasespolymorphNorvir®ritonavirpoorly soluble compoundpediatricpalatability assessmentbioavailabilityflavor profileInterleukin-1anakinracanakinumabinnovative biotechnologiesautoinflammatory diseaseKawasaki diseasesystemic juvenile idiopathic arthritispersonalized medicinechildpediatricsneonatesformulationproduct developmentformulation developmentoralparenteraltopicalinhaledintra nasalbiopharmaceuticsadministrationexcipientNICUdevicemedication errordosage formmodified releasedrug deliverypaediatric formulation developmentpaediatric dosage formschronic myeloid leukemiatyrosine kinase inhibitorspediatric ageimatinibnilotinbponatinibOrodispersible formulationpyrazinamidepediatric drug deliverytuberculosisdesign of experimentschildrenedible filmsdevelopmentdesignpaediatricage-relatedpalatabletaste-maskingacceptableMedicineDenora Nunzioedt1322374Lopalco AntonioedtDenora NunzioothLopalco AntonioothBOOK9910557304003321Paediatric Formulation: Design and Development3034926UNINA