LEADER 00823nam0 2200277 450 001 9910209157803321 005 20170630073654.0 010 $a9788898774418 100 $a20170628d2017----km y0itay50 ba 101 0 $aita$aeng 105 $a 001yy 200 1 $aEsperienze dell'architettura$eCorvino + Multari 210 $a[S.l.]$cLISt Lab$d2017 215 $a173 p.$cill.$d31 cm 225 1 $aMonograph.it collection$vXL 510 1 $aArchitecture experiences$eCorvino + Multari 517 1 $aCorvino pių Multari 700 1$bCorvino,$bVincenzo$010796 701 1$aMultari,$bGiovanni$010798 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910209157803321 952 $aARCH C 1085$b86/2017$fFARBC 959 $aFARBC 996 $aEsperienze dell'architettura$91466682 997 $aUNINA LEADER 04654nam 2201261z- 450 001 9910557304003321 005 20220111 035 $a(CKB)5400000000042816 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76438 035 $a(oapen)doab76438 035 $a(EXLCZ)995400000000042816 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPaediatric Formulation: Design and Development 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (205 p.) 311 08$a3-0365-0740-X 311 08$a3-0365-0741-8 330 $aThe development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients. 517 $aPaediatric Formulation 606 $aMedicine$2bicssc 610 $aacceptable 610 $aadministration 610 $aage-related 610 $aanakinra 610 $aautoinflammatory disease 610 $abioavailability 610 $abiopharmaceutics 610 $acanakinumab 610 $achild 610 $achildren 610 $achronic myeloid leukemia 610 $aconfocal microscopy 610 $acyclodextrin inclusion complex 610 $adasatinib 610 $adesign 610 $adesign of experiments 610 $adevelopment 610 $adevice 610 $adosage form 610 $adrug delivery 610 $aDuchenne muscular dystrophy 610 $aedible films 610 $aexcipient 610 $aflavor profile 610 $aformulation 610 $aformulation development 610 $agrinding 610 $aimatinib 610 $ainhaled 610 $ainnovative biotechnologies 610 $aInterleukin-1 610 $aintra nasal 610 $aKawasaki disease 610 $aliquid formulation 610 $amedication error 610 $amodified release 610 $aneglected tropical diseases 610 $aneonates 610 $aNICU 610 $anilotinb 610 $aNorvirŪ 610 $aoral 610 $aOrodispersible formulation 610 $apaediatric 610 $apaediatric age 610 $apaediatric dosage forms 610 $apaediatric formulation development 610 $apalatability assessment 610 $apalatable 610 $aparenteral 610 $apediatric 610 $apediatric age 610 $apediatric drug delivery 610 $apediatrics 610 $apenetration 610 $apersonalized medicine 610 $aphase solubility studies 610 $apolymorph 610 $aponatinib 610 $apoorly soluble compound 610 $apoorly water soluble drug 610 $aproduct development 610 $apyrazinamide 610 $aretinoblastoma 610 $aritonavir 610 $asolubility enhancement 610 $aspray congealing 610 $asystemic juvenile idiopathic arthritis 610 $ataste-masking 610 $atopical 610 $atopotecan 610 $atuberculosis 610 $atumorspheres 610 $atyrosine kinase inhibitors 615 7$aMedicine 700 $aDenora$b Nunzio$4edt$01322374 702 $aLopalco$b Antonio$4edt 702 $aDenora$b Nunzio$4oth 702 $aLopalco$b Antonio$4oth 906 $aBOOK 912 $a9910557304003321 996 $aPaediatric Formulation: Design and Development$93034926 997 $aUNINA LEADER 03760nam 2201009z- 450 001 9910404078403321 005 20210211 010 $a3-03928-810-5 035 $a(CKB)4100000011302354 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41450 035 $a(oapen)doab41450 035 $a(EXLCZ)994100000011302354 100 $a20202102d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAssessment of Energy-Environment-Economy Interrelations 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (274 p.) 311 08$a3-03928-809-1 330 $aEnergy consumption and economic growth have been of great interest to researchers and policy-makers. Knowing the actual causal relationship between energy and the economy with respect to environmental degradation has important implications for modeling environmental and growth policies. The eleven chapters included herein aim to help researchers, academicians, and especially decision-makers to understand relevant issues and adopt appropriate methods to tackle and solve relevant environmental problems. Various methods from different disciplines are proposed and applied to various environmental and energy issues. 606 $aHistory of engineering and technology$2bicssc 610 $a3E 610 $aAnalytic Hierarchy Process 610 $aAnalytic Network Process 610 $acarbon emissions 610 $acircular economy 610 $acost allocation 610 $adata envelopment analysis 610 $adecoupling theory 610 $adifferential games 610 $adifferential GMM estimation 610 $adistrict distributed power plants 610 $adynamic hybrid input-output model 610 $aeconomic benefit evaluation 610 $aeconomic systems 610 $aeconomy 610 $aeffectiveness 610 $aembodied energy 610 $aenergy 610 $aenergy commodities 610 $aenergy consumption 610 $aenergy recovery 610 $aenergy-related carbon emissions 610 $aenvironment 610 $aenvironment quality cointegration 610 $aenvironmental efficiency 610 $aenvironmental engineering 610 $aenvironmental Kuznets curve (EKC) 610 $aexpected utility maximization 610 $afinancial development 610 $afixed assets investment 610 $ahedging strategies 610 $aindustrial CO2 emission 610 $aindustrialization 610 $aKaya identity 610 $alife cycle cost 610 $alinearization 610 $aLMDI approach 610 $aMESSAGE model 610 $aminimum-variance hedge ratio 610 $aMulti-Criteria Decision Analysis 610 $aopen-loop control systems 610 $aPakistan 610 $apanel data 610 $arank reversal 610 $aresource dependence theory 610 $arisk aversion 610 $asensitivity analysis 610 $aShapley value 610 $astructural decomposition analysis 610 $asustainability 610 $asustainable development 610 $asustainable wind energy management 610 $aTapio decoupling model 610 $athermodynamic cycles 610 $auncertain dynamic systems 610 $aurban utility tunnel 610 $awaste 615 7$aHistory of engineering and technology 700 $aHalkos$b George$4auth$01332352 906 $aBOOK 912 $a9910404078403321 996 $aAssessment of Energy-Environment-Economy Interrelations$94417544 997 $aUNINA