Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / / Kuan Hu
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| Autore: |
Hu Kuan
|
| Titolo: |
Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / / Kuan Hu
|
| Pubblicazione: | Singapore : , : Springer, , [2021] |
| ©2021 | |
| Edizione: | 1st ed. 2021. |
| Descrizione fisica: | 1 online resource (XV, 102 p. 75 illus., 65 illus. in color.) |
| Disciplina: | 547.756 |
| Soggetto topico: | Peptides - Synthesis |
| Cancer - Research | |
| Peptides - Biotechnology | |
| Chemistry Techniques, Synthetic | |
| Peptides - therapeutic use | |
| Peptides, Cyclic | |
| Biomedical Research | |
| Nota di contenuto: | Introduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide. |
| Sommario/riassunto: | This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. . |
| Titolo autorizzato: | Development of In-Tether Carbon Chiral Center-Induced Helical Peptide |
| ISBN: | 981-336-613-3 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910484381203321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Springer theses.