03041nam 2200601 450 991048438120332120240124234403.0981-336-613-310.1007/978-981-33-6613-8(CKB)4100000011743155(DE-He213)978-981-33-6613-8(MiAaPQ)EBC6463810(PPN)253250927(EXLCZ)99410000001174315520210405d2021 uy 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierDevelopment of in-tether carbon chiral center-induced helical peptide methodology and applications /Kuan Hu1st ed. 2021.Singapore :Springer,[2021]©20211 online resource (XV, 102 p. 75 illus., 65 illus. in color.)Springer Theses981-336-612-5 Introduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide.This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. .Springer theses.PeptidesSynthesisCancerResearchPeptidesBiotechnologyChemistry Techniques, SyntheticPeptidestherapeutic usePeptides, CyclicBiomedical ResearchPeptidesSynthesis.CancerResearch.PeptidesBiotechnology.Chemistry Techniques, Synthetic.Peptidestherapeutic use.Peptides, Cyclic.Biomedical Research.547.756Hu Kuan1223385MiAaPQMiAaPQMiAaPQBOOK9910484381203321Development of In-Tether Carbon Chiral Center-Induced Helical Peptide2837879UNINA