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[null,"1.","Record Nr.",null,"UNISALENTO991002339799707536"]
[null,null,"Autore",null,"Jolivet, Vincent, 1955-"]
[null,null,"Titolo",null,"Tristes portiques : sur le plan canonique de la maison étrusque et romaine des origines au principat d'Auguste (VIe-Ier siècles av. J.-C.) / par Vincent Jolivet"]
[null,null,"Pubbl/distr/stampa",null,"Rome : Ecole française de Rome, 2011"]
[null,null,"ISBN",null,"9782728308750"]
[null,null,"Descrizione fisica",null,"X, 343 p. : ill. ; 29 cm."]
[null,null,"Collana",null,"Bibliothèque des Écoles françaises d'Athènes et de Rome ; 342"]
[null,null,"Soggetti",null,"Architettura domestica - Roma"]
[{"$nulls":4},"Architettura romana"]
[{"$nulls":4},"Architettura etrusca"]
[{"$nulls":4},"Roma Storia Republica, 510 - 30 a. C."]
[{"$nulls":4},"Roma Storia Augusto, 30 a. C. - 14 d. C."]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Contiene bibliografia: pp. [281]-321"]
[null,"2.","Record Nr.",null,"UNINA9910484381203321"]
[null,null,"Autore",null,"Hu Kuan"]
[null,null,"Titolo",null,"Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / / Kuan Hu"]
[null,null,"Pubbl/distr/stampa",null,"Singapore : , : Springer, , [2021]"]
[{"$nulls":4},"©2021"]
[null,null,"ISBN",null,"981-336-613-3"]
[null,null,"Edizione",null,"[1st ed. 2021.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XV, 102 p. 75 illus., 65 illus. in color.)"]
[null,null,"Collana",null,"Springer Theses"]
[null,null,"Disciplina",null,"547.756"]
[null,null,"Soggetti",null,"Peptides - Synthesis"]
[{"$nulls":4},"Cancer - Research"]
[{"$nulls":4},"Peptides - Biotechnology"]
[{"$nulls":4},"Chemistry Techniques, Synthetic"]
[{"$nulls":4},"Peptides - therapeutic use"]
[{"$nulls":4},"Peptides, Cyclic"]
[{"$nulls":4},"Biomedical Research"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Introduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide."]
[null,null,null,"Sommario/riassunto","This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled "]
[{"$nulls":4},"peptide drugs. ."]