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1. |
Record Nr. |
UNINA9910484381203321 |
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Autore |
Hu Kuan |
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Titolo |
Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / / Kuan Hu |
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Pubbl/distr/stampa |
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Singapore : , : Springer, , [2021] |
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©2021 |
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ISBN |
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Edizione |
[1st ed. 2021.] |
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Descrizione fisica |
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1 online resource (XV, 102 p. 75 illus., 65 illus. in color.) |
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Collana |
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Disciplina |
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Soggetti |
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Peptides - Synthesis |
Cancer - Research |
Peptides - Biotechnology |
Chemistry Techniques, Synthetic |
Peptides - therapeutic use |
Peptides, Cyclic |
Biomedical Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Introduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide. |
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Sommario/riassunto |
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This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only |
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advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. . |
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2. |
Record Nr. |
UNINA9910585995003321 |
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Autore |
Wendler Philipp |
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Titolo |
Worked to the Bone : A Study of Gilded-Age Transatlantic Scientific Networks in Paleontology |
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Pubbl/distr/stampa |
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Hamburg, : Hamburg University Press, 2022 |
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Descrizione fisica |
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1 online resource (434 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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In the American "Wild West" the nation's predominant paleontologists O. C. Marsh and E. D. Cope raced for the discovery of the most spectacular dinosaur fossils the world had ever seen. The "Bone Wars" not only unearthed triceratops, stegosaurus, and brontosaurus, they also made US paleontology world-famous. This book analyzes international scientific networks, carves out German influences on the evolution of US paleontology and higher education, and examines the link between the rise of US nationalism and science. So-far neglected by scholars, the perspectives of O. C. Marsh's German assistants take center stage. |
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