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Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges



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Autore: Gabazza Esteban C Visualizza persona
Titolo: Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges Visualizza cluster
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute, 2019
Descrizione fisica: 1 electronic resource (348 p.)
Soggetto non controllato: bleomycin
regeneration
antitumor efficacy
lung cancer
SOX2
leiomyosarcoma
lung cancer (LC)
nanoparticles
cytokines
hepatocellular carcinoma
metabolic reprogramming
hepatic stellate cells
angiogenesis
transforming growth factor-?
anaplastic lymphoma kinase
idiopathic pulmonary fibrosis
growth factor
pathogenesis
cancer-associated fibroblasts
fibrosis
lipopolysaccharide
DHA
lncRNA
SREBP-1
YAP
protein S
non-small cell lung cancer (NSCLC)
omega-3 fatty acid
inflammation
metastasis
clinical symptoms
miRNA
smooth muscle tumor of uncertain malignant potential
Wnt
interstitial fluid pressure
heterogeneity
hepatocytes
myometrium
tumor necrosis factor ?
tumor
tumor microenvironment
extracellular matrix
TAZ
carcinogenesis
cystic formation
pulmonary fibrosis
HBV
cytokine
genetic instability
diagnosis
EMT
crizotinib
Hippo pathway
GPR120
marker
HCV
non-alcoholic steatohepatitis
pathology
common pathways
apoptosis
type I collagen
GPR40
acute lung injury
uterine fibroid
renal injury
pathophysiology
reactive oxygen species
immunohistochemistry
SMAD
butylidenephthalide
leiomyoma
cirrhosis
Erk1/2
targeted therapy
TGF-?
mechanotransduction
therapy
breast cancer
hepatocellular carcinoma (HCC)
hepatic stellate cells (HSCs)
idiopathic pulmonary fibrosis (IPF)
cancer-associated fibroblasts (CAFs)
cancer
signal pathway
tumor stiffness
Sommario/riassunto: Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.
Altri titoli varianti: Links between Fibrogenesis and Cancer
Titolo autorizzato: Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges  Visualizza cluster
ISBN: 3-03921-707-0
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910367745903321
Lo trovi qui: Univ. Federico II
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