LEADER 05156nam 2201369z- 450 001 9910367745903321 005 20210211 010 $a3-03921-707-0 035 $a(CKB)4100000010106258 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/51774 035 $a(oapen)doab51774 035 $a(EXLCZ)994100000010106258 100 $a20202102d2019 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aLinks between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 215 $a1 online resource (348 p.) 311 08$a3-03921-706-2 330 $aTissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs. 517 $aLinks between Fibrogenesis and Cancer 606 $aMedicine$2bicssc 610 $aacute lung injury 610 $aanaplastic lymphoma kinase 610 $aangiogenesis 610 $aantitumor efficacy 610 $aapoptosis 610 $ableomycin 610 $abreast cancer 610 $abutylidenephthalide 610 $acancer 610 $acancer-associated fibroblasts 610 $acancer-associated fibroblasts (CAFs) 610 $acarcinogenesis 610 $acirrhosis 610 $aclinical symptoms 610 $acommon pathways 610 $acrizotinib 610 $acystic formation 610 $acytokine 610 $acytokines 610 $aDHA 610 $adiagnosis 610 $aEMT 610 $aErk1/2 610 $aextracellular matrix 610 $afibrosis 610 $agenetic instability 610 $aGPR120 610 $aGPR40 610 $agrowth factor 610 $aHBV 610 $aHCV 610 $ahepatic stellate cells 610 $ahepatic stellate cells (HSCs) 610 $ahepatocellular carcinoma 610 $ahepatocellular carcinoma (HCC) 610 $ahepatocytes 610 $aheterogeneity 610 $aHippo pathway 610 $aidiopathic pulmonary fibrosis 610 $aidiopathic pulmonary fibrosis (IPF) 610 $aimmunohistochemistry 610 $ainflammation 610 $ainterstitial fluid pressure 610 $aleiomyoma 610 $aleiomyosarcoma 610 $alipopolysaccharide 610 $alncRNA 610 $alung cancer 610 $alung cancer (LC) 610 $amarker 610 $amechanotransduction 610 $ametabolic reprogramming 610 $ametastasis 610 $amiRNA 610 $amyometrium 610 $an/a 610 $ananoparticles 610 $anon-alcoholic steatohepatitis 610 $anon-small cell lung cancer (NSCLC) 610 $aomega-3 fatty acid 610 $apathogenesis 610 $apathology 610 $apathophysiology 610 $aprotein S 610 $apulmonary fibrosis 610 $areactive oxygen species 610 $aregeneration 610 $arenal injury 610 $asignal pathway 610 $aSMAD 610 $asmooth muscle tumor of uncertain malignant potential 610 $aSOX2 610 $aSREBP-1 610 $atargeted therapy 610 $aTAZ 610 $aTGF-? 610 $atherapy 610 $atransforming growth factor-? 610 $atumor 610 $atumor microenvironment 610 $atumor necrosis factor ? 610 $atumor stiffness 610 $atype I collagen 610 $auterine fibroid 610 $aWnt 610 $aYAP 615 7$aMedicine 700 $aGabazza$b Esteban C$4auth$01288168 906 $aBOOK 912 $a9910367745903321 996 $aLinks between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges$93020666 997 $aUNINA LEADER 01948nam 2200457z- 450 001 9910557896903321 005 20211118 035 $a(CKB)5400000000046311 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/74310 035 $a(oapen)doab74310 035 $a(EXLCZ)995400000000046311 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aImmune-Modulatory Effects of Vitamin D 210 $cFrontiers Media SA$d2020 215 $a1 online resource (177 p.) 311 08$a2-88966-174-1 330 $aThis eBook is a collection of articles from a Frontiers Research Topic. 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Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact 606 $aImmunology$2bicssc 606 $aMedicine and Nursing$2bicssc 610 $aimmune modulation 610 $ainfection 610 $amonocytes 610 $aT cells 610 $avitamin D 615 7$aImmunology 615 7$aMedicine and Nursing 700 $aZughaier$b Susu M$4edt$01320407 702 $aLubberts$b Erik$4edt 702 $aBener$b Abdulbari$4edt 702 $aZughaier$b Susu M$4oth 702 $aLubberts$b Erik$4oth 702 $aBener$b Abdulbari$4oth 906 $aBOOK 912 $a9910557896903321 996 $aImmune-Modulatory Effects of Vitamin D$93034271 997 $aUNINA LEADER 06332nam 22008415 450 001 9910483801503321 005 20251116133907.0 010 $a9789401793551 010 $a9401793557 024 7 $a10.1007/978-94-017-9355-1 035 $a(CKB)3710000000342675 035 $a(EBL)1966738 035 $a(SSID)ssj0001424501 035 $a(PQKBManifestationID)11891210 035 $a(PQKBTitleCode)TC0001424501 035 $a(PQKBWorkID)11363949 035 $a(PQKB)10295193 035 $a(DE-He213)978-94-017-9355-1 035 $a(MiAaPQ)EBC1966738 035 $a(PPN)183516761 035 $a(EXLCZ)993710000000342675 100 $a20150120d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aIndigenous Education $eLanguage, Culture and Identity /$fedited by W. James Jacob, Sheng Yao Cheng, Maureen K. Porter 205 $a1st ed. 2015. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015. 215 $a1 online resource (475 p.) 300 $aDescription based upon print version of record. 311 08$a9789401793544 311 08$a9401793549 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aForeword -- Preface -- 1. Global Review of Indigenous Education: Issues of Identity, Culture, and Language. W. James Jacob, Sheng Yao Cheng, and Maureen K. Porter -- Section I: Thematic Issues on Indigenous Education -- 2. Policy Debates and Indigenous Education: The Trialectic of Language, Culture, and Identity. W. James Jacob, Jing Liu, and Che-Wei Lee -- 3. ICT and Indigenous Education: Emerging Challenges and Potential Solutions. Rebecca A. Clothey -- 4. Formal and Informal Indigenous Education. Terry Wotherspoon -- 5. Indigenous Higher Education. Duane W. Champagne -- 6. Indigenous Chinese Higher Education: John N. Hawkins -- Section II: Language -- 7. Strategies for Overcoming Linguistic Genocide: How to Avoid Macroaggressions and Microaggressions that Lead toward Indigenous Language Annihilation. W. James Jacob -- 8. Sustaining Indigenous Identity through Language Development: Comparing Indigenous Language Instructionin Two Contexts: Carol J. Ward and David B. Braudt -- 9. Language-in-Education Policies in Africa: Perspectives, Practices, and Implications: Connie Ssebbunga-Masembe, Christopher B. Mugimu, Anthony Mugagga, and Stephen Backman -- 10. The Sami People in Scandinavia: Government Policies for Indigenous Language Recognition and Support in the Formal Education System: Mina O?Dowd -- 11. Learning from the Moa: The Challenge of Maori Language Revitalization in Aotearoa/New Zealand. Roger Boshier -- 12. Heteroglossia: Reframing the Conversation around Literacy Achievement for English Language Learners and American Indian/Alaska Native Students: Evelisa Natasha Genova and Lydia Ross -- Section III: Culture -- 13. Somos Incas: Enduring Cultural Sensibilities and Indigenous Education. Maureen K. Porter -- 14. Indigenous History, Culture, and Education in the Pacific Islands. Richard Scaglion -- 15. Reclaiming Indigenous Cultures in African Education. Edward Shizha -- 16. Indigenous Knowledges in Education: Anticolonial Struggles in a Monocultural Arena with Reference to Chile and South America. Anders Breidlid and Louis Royce Botha -- 17. The Role of Schools in Native American Language and Culture Revitalization: A Vision of Linguistic and Educational Sovereignty. Teresa L. McCarty and Tiffany S. Lee -- 18. Between the Community and the Individual: Identity in Intercultural Education in Mexico. Rocío Fuentes -- Section IV: Identity -- 19. Beyond the Cultural Turn: Indigenous Identity and Mainstream Identity. Sheng Yao Cheng -- 20. Idigeneity and Global Citizenship. Jerome M. Levi and Elizabeth Durham -- 21. Indigenous Identity and Education in Peruvian Amazonia. Bartholomew Dean -- 22. Intersections of Identity and Education: The Native American Experience. Hilary N. Weaver -- Index. 330 $aIndigenous Education is a compilation of conceptual chapters and national case studies that includes empirical research based on a series of data collection methods. The book provides up-to-date scholarly research on global trends on three issues of paramount importance with indigenous education?language, culture, and identity. It also offers a strategic comparative and international education policy statement on recent shifts in indigenous education, and new approaches to explore, develop, and improve comparative education and policy research globally. Contributing authors examine several social justice issues related to indigenous education. In addition to case perspectives from 12 countries and global regions, the volume includes five conceptual chapters on topics that influence indigenous education, including policy debates, the media, the united nations, formal and informal education systems, and higher education. 606 $aInternational education 606 $aComparative education 606 $aAnthropology 606 $aEducation and state 606 $aEducation, Higher 606 $aEducational sociology 606 $aInternational and Comparative Education 606 $aAnthropology 606 $aEducational Policy and Politics 606 $aHigher Education 606 $aSociology of Education 615 0$aInternational education. 615 0$aComparative education. 615 0$aAnthropology. 615 0$aEducation and state. 615 0$aEducation, Higher. 615 0$aEducational sociology. 615 14$aInternational and Comparative Education. 615 24$aAnthropology. 615 24$aEducational Policy and Politics. 615 24$aHigher Education. 615 24$aSociology of Education. 676 $a301 676 $a306.43 676 $a370 676 $a370.9 676 $a370116 676 $a378 676 $a379 702 $aJacob$b W. 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