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1. |
Record Nr. |
UNISA996388738303316 |
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Titolo |
By the King, a proclamation, for apprehending James Butler, late Duke of Ormond, and other persons attainted of high treason on account of the late rebellion [[electronic resource]] |
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Pubbl/distr/stampa |
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London, : printed by John Baskett, printer to the Kings most excellent Majesty, and by the assigns of Thomas Newcomb, and Henry Hills, deceas'd, 1718 [i.e. 1719] |
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Descrizione fisica |
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Altri autori (Persone) |
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George, King of Great Britain, <1660-1727.> |
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Soggetti |
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Jacobite Rebellion, 1719 |
Jacobites - Great Britain |
Fugitives from justice - Great Britain |
Bounties - Great Britain |
Great Britain History George I, 1714-1727 Early works to 1800 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Given at our court at St. James's, the fifteenth day of March, 1718. in the fifth year of our reign.". |
Dates given according to Lady Day dating. |
Steele notation: of sturb Com-. Press figure 6 under the first line of imprint on the right. |
Reproduction of original in the British Library. |
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2. |
Record Nr. |
UNINA9910367745903321 |
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Autore |
Gabazza Esteban C |
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Titolo |
Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
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ISBN |
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Descrizione fisica |
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1 online resource (348 p.) |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs. |
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