T Cell Differentiation and Function in Tissue Inflammation

• Autore: Awasthi Amit
• Pubblicazione: Frontiers Media SA, 2020
• Descrizione fisica: 1 electronic resource (231 p.)
• Soggetto topico: Medicine; Immunology
• Soggetto non controllato: CD4 T cell; CD8 T cell; Cancer; autoimmune disease; Inflammation
• Persona (resp. second.): GoswamiRitobrata; AwasthiAmit
• Sommario/riassunto: Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.
• Titolo autorizzato: T Cell Differentiation and Function in Tissue Inflammation
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557255203321
• Lo trovi qui: Univ. Federico II