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[null,"1.","Record Nr.",null,"UNINA9910557255203321"]
[null,null,"Autore",null,"Awasthi Amit"]
[null,null,"Titolo",null,"T Cell Differentiation and Function in Tissue Inflammation"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2020"]
[null,null,"Descrizione fisica",null,"1 online resource (231 p.)"]
[null,null,"Soggetti",null,"Immunology"]
[{"$nulls":4},"Medicine and Nursing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors."]