02067nam 2200421z- 450 991055725520332120231214133045.0(CKB)5400000000041405(oapen)https://directory.doabooks.org/handle/20.500.12854/73756(EXLCZ)99540000000004140520202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierT Cell Differentiation and Function in Tissue InflammationFrontiers Media SA20201 electronic resource (231 p.)2-88963-614-3 Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.MedicinebicsscImmunologybicsscCD4 T cellCD8 T cellCancerautoimmune diseaseInflammationMedicineImmunologyAwasthi Amitedt1302748Goswami RitobrataedtAwasthi AmitothGoswami RitobrataothBOOK9910557255203321T Cell Differentiation and Function in Tissue Inflammation3026510UNINA