Receptor tyrosine kinases [[electronic resource] ] : function, families and evolution / / Tony Hunter

• Autore: Hunter Tony <1943-, >
• Pubblicazione: London, : Henry Stewart Talks, 2007
• Descrizione fisica: 1 online resource (1 streaming video file (53 min.) : color, sound)
• Soggetto topico: Hormones; Receptor Protein-Tyrosine Kinases; Signal Transduction
• Note generali: Animated audio-visual presentation with synchronized narration.; Title from title frames.
• Nota di contenuto: Contents: History of protein phosphorylation -- Protein kinase bioinformatics -- History of tyrosine phosphorylation and functions of tyrosine kinases -- Genomic catalogues of protein kinases (kinomes) -- The human kinome -- The evolution of kinomes -- The human tyrosine kinase subfamily -- Receptor and nonreceptor tyrosine kinases -- Activation of receptor tyrosine kinases by ligand-induced dimerization -- Signal transduction pathways downstream of receptor tyrosine kinases -- Insulin and IOGF-1 receptor signaling via the mTOR pathway -- mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance -- History of Eph receptor tyrosine kinases and their ephrin ligands -- Bidirectional signaling via Eph-ephrin interactions on neighboring cells -- Simultaneous signaling by EphAs and ephrin As in motor neurons -- Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains -- Protein kinases and human disease -- Human cancer genes and protein kinases -- Protein kinases and phosphatases and cancer -- The long road to Gleevec.
• Titolo autorizzato: Receptor tyrosine kinases
• Formato: Videoregistrazioni
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910596998503321
• Lo trovi qui: Univ. Federico II
• Serie: Henry Stewart talks. . -Biomedical & life sciences collection. . -Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.; Henry Stewart talks. . -Biomedical & life sciences collection. . -World of hormones : molecular and physiological insights.