LEADER 02904ngm  2200409 a 450 
001 9910596998503321
005 20231116231051.0
035   $a(CKB)3780000000051585
035   $a(UkLU-K)AC000392050
035   $a(EXLCZ)993780000000051585
071 50$a1179$bHenry Stewart Talks
100   $a20080121d2007      ||         v
101 0 $aeng
135   $aurcna|||a||||
200 10$aReceptor tyrosine kinases$b[electronic resource] $efunction, families and evolution /$fTony Hunter
210   $aLondon $cHenry Stewart Talks$d2007
215   $a1 online resource (1 streaming video file (53 min.) $ccolor, sound)
225 1 $aSignal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease,$x2056-452X
225 1 $aThe world of hormones : molecular and physiological insights,$x2056-452X
300   $aAnimated audio-visual presentation with synchronized narration.
300   $aTitle from title frames.
327   $aContents: History of protein phosphorylation -- Protein kinase bioinformatics -- History of tyrosine phosphorylation and functions of tyrosine kinases -- Genomic catalogues of protein kinases (kinomes) -- The human kinome -- The evolution of kinomes -- The human tyrosine kinase subfamily -- Receptor and nonreceptor tyrosine kinases -- Activation of receptor tyrosine kinases by ligand-induced dimerization -- Signal transduction pathways downstream of receptor tyrosine kinases -- Insulin and IOGF-1 receptor signaling via the mTOR pathway -- mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance -- History of Eph receptor tyrosine kinases and their ephrin ligands -- Bidirectional signaling via Eph-ephrin interactions on neighboring cells -- Simultaneous signaling by EphAs and ephrin As in motor neurons -- Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains -- Protein kinases and human disease -- Human cancer genes and protein kinases -- Protein kinases and phosphatases and cancer -- The long road to Gleevec.
410  0$aHenry Stewart talks.$pBiomedical & life sciences collection.$pSignal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.
410  0$aHenry Stewart talks.$pBiomedical & life sciences collection.$pWorld of hormones : molecular and physiological insights.
606   $aHormones
606   $aReceptor Protein-Tyrosine Kinases
606   $aSignal Transduction
615  2$aHormones.
615  2$aReceptor Protein-Tyrosine Kinases.
615  2$aSignal Transduction.
700   $aHunter$b Tony$f1943-,$4spk$0470507
801  0$bUkLU-K
801  1$bUkLU-K
906   $aVIDEO
912   $a9910596998503321
996   $aReceptor tyrosine kinases$92929364
997   $aUNINA