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[null,"1.","Record Nr.",null,"UNINA9910596998503321"]
[null,null,"Autore",null,"Hunter Tony <1943-, >"]
[null,null,"Titolo",null,"Receptor tyrosine kinases [[electronic resource] ] : function, families and evolution / / Tony Hunter"]
[null,null,"Pubbl/distr/stampa",null,"London, : Henry Stewart Talks, 2007"]
[null,null,"Descrizione fisica",null,"1 online resource (1 streaming video file (53 min.) : color, sound)"]
[null,null,"Collana",null,"Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease, , 2056-452X"]
[{"$nulls":4},"The world of hormones : molecular and physiological insights, , 2056-452X"]
[null,null,"Soggetti",null,"Hormones"]
[{"$nulls":4},"Receptor Protein-Tyrosine Kinases"]
[{"$nulls":4},"Signal Transduction"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Videoregistrazione"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Animated audio-visual presentation with synchronized narration."]
[{"$nulls":4},"Title from title frames."]
[null,null,"Nota di contenuto",null,"Contents: History of protein phosphorylation -- Protein kinase bioinformatics -- History of tyrosine phosphorylation and functions of tyrosine kinases -- Genomic catalogues of protein kinases (kinomes) -- The human kinome -- The evolution of kinomes -- The human tyrosine kinase subfamily -- Receptor and nonreceptor tyrosine kinases -- Activation of receptor tyrosine kinases by ligand-induced dimerization -- Signal transduction pathways downstream of receptor tyrosine kinases -- Insulin and IOGF-1 receptor signaling via the mTOR pathway -- mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance -- History of Eph receptor tyrosine kinases and their ephrin ligands -- Bidirectional signaling via Eph-ephrin interactions on neighboring cells -- Simultaneous signaling by EphAs and ephrin As in motor neurons -- Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains -- Protein kinases and human disease -- Human cancer genes and protein kinases -- Protein kinases and phosphatases and cancer -- The long road to Gleevec."]