RNA interference [[electronic resource] ] : application to drug discovery and challenges to pharmaceutical development / / edited by Paul H. Johnson

• Pubblicazione: Hoboken, N.J., : Wiley, c2011
• Descrizione fisica: 1 online resource (330 p.)
• Disciplina: 572.8/8; 572.88
• Soggetto topico: Drug development; RNA; Small interfering RNA
• Altri autori: JohnsonPaul H. <1943->
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: RNA INTERFERENCE; CONTENTS; CONTRIBUTORS; PREFACE; FOREWORD; I BIOLOGY OF RNA INTERFERENCE; 1 RNA INTERFERENCE: WHAT IS IT?; 2 NUCLEIC ACIDS AS REGULATORY MOLECULES; 3 USE OF SIRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION; 4 GENOME SCANNING BY RNA INTERFERENCE; II DEVELOPMENT OF SIRNA FOR THERAPEUTIC APPLICATIONS; 5 DISCOVERY OF NEW SIRNA DELIVERY AGENTS; 6 SIRNA DELIVERY VEHICLES; 7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES; 8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES; INDEX; Color Plate
• Sommario/riassunto: RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
• Titolo autorizzato: RNA interference
• ISBN: 0-470-93467-0; 1-282-90488-4; 9786612904882; 0-470-92372-5; 0-470-92373-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910133585103321
• Lo trovi qui: Univ. Federico II