1.

Record Nr.

UNINA9910133585103321

Titolo

RNA interference [[electronic resource] ] : application to drug discovery and challenges to pharmaceutical development / / edited by Paul H. Johnson

Pubbl/distr/stampa

Hoboken, N.J., : Wiley, c2011

ISBN

0-470-93467-0

1-282-90488-4

9786612904882

0-470-92372-5

0-470-92373-3

Descrizione fisica

1 online resource (330 p.)

Altri autori (Persone)

JohnsonPaul H. <1943->

Disciplina

572.8/8

572.88

Soggetti

Drug development

RNA

Small interfering RNA

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

RNA INTERFERENCE; CONTENTS; CONTRIBUTORS; PREFACE; FOREWORD; I BIOLOGY OF RNA INTERFERENCE; 1 RNA INTERFERENCE: WHAT IS IT?; 2 NUCLEIC ACIDS AS REGULATORY MOLECULES; 3 USE OF SIRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION; 4 GENOME SCANNING BY RNA INTERFERENCE; II DEVELOPMENT OF SIRNA FOR THERAPEUTIC APPLICATIONS; 5 DISCOVERY OF NEW SIRNA DELIVERY AGENTS; 6 SIRNA DELIVERY VEHICLES; 7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES; 8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES; INDEX; Color Plate

Sommario/riassunto

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small



interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.