02771nam 2200601Ia 450 991013358510332120170815153211.00-470-93467-01-282-90488-497866129048820-470-92372-50-470-92373-3(CKB)3400000000000285(EBL)675107(OCoLC)730151634(SSID)ssj0000441875(PQKBManifestationID)11312658(PQKBTitleCode)TC0000441875(PQKBWorkID)10444947(PQKB)11756604(MiAaPQ)EBC675107(PPN)243350589(EXLCZ)99340000000000028520100804d2011 uy 0engur|n|---|||||txtccrRNA interference[electronic resource] application to drug discovery and challenges to pharmaceutical development /edited by Paul H. JohnsonHoboken, N.J. Wileyc20111 online resource (330 p.)Description based upon print version of record.0-471-77151-1 Includes bibliographical references and index.RNA INTERFERENCE; CONTENTS; CONTRIBUTORS; PREFACE; FOREWORD; I BIOLOGY OF RNA INTERFERENCE; 1 RNA INTERFERENCE: WHAT IS IT?; 2 NUCLEIC ACIDS AS REGULATORY MOLECULES; 3 USE OF SIRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION; 4 GENOME SCANNING BY RNA INTERFERENCE; II DEVELOPMENT OF SIRNA FOR THERAPEUTIC APPLICATIONS; 5 DISCOVERY OF NEW SIRNA DELIVERY AGENTS; 6 SIRNA DELIVERY VEHICLES; 7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES; 8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES; INDEX; Color PlateRNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.Drug developmentRNASmall interfering RNADrug development.RNA.Small interfering RNA.572.8/8572.88Johnson Paul H.1943-907074MiAaPQMiAaPQMiAaPQBOOK9910133585103321RNA interference2029007UNINA