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[null,"1.","Record Nr.",null,"UNINA9910133585103321"]
[null,null,"Titolo",null,"RNA interference [[electronic resource] ] : application to drug discovery and challenges to pharmaceutical development / / edited by Paul H. Johnson"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley, c2011"]
[null,null,"ISBN",null,"0-470-93467-0"]
[{"$nulls":4},"1-282-90488-4"]
[{"$nulls":4},"9786612904882"]
[{"$nulls":4},"0-470-92372-5"]
[{"$nulls":4},"0-470-92373-3"]
[null,null,"Descrizione fisica",null,"1 online resource (330 p.)"]
[null,null,"Disciplina",null,"572.8/8"]
[{"$nulls":4},"572.88"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"RNA"]
[{"$nulls":4},"Small interfering RNA"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"RNA INTERFERENCE; CONTENTS; CONTRIBUTORS; PREFACE; FOREWORD; I BIOLOGY OF RNA INTERFERENCE; 1 RNA INTERFERENCE: WHAT IS IT?; 2 NUCLEIC ACIDS AS REGULATORY MOLECULES; 3 USE OF SIRNA OLIGONUCLEOTIDES TO STUDY GENE FUNCTION; 4 GENOME SCANNING BY RNA INTERFERENCE; II DEVELOPMENT OF SIRNA FOR THERAPEUTIC APPLICATIONS; 5 DISCOVERY OF NEW SIRNA DELIVERY AGENTS; 6 SIRNA DELIVERY VEHICLES; 7 INTERFERON, CYTOKINE INDUCTION, AND OTHER POTENTIAL IN VIVO TOXICITIES; 8 APPLICATION OF RNA INTERFERENCE TO VIRAL DISEASES; INDEX; Color Plate"]
[null,null,null,"Sommario/riassunto","RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects."]