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Autore: | Hu Kuan |
Titolo: | Development of in-tether carbon chiral center-induced helical peptide : methodology and applications / / Kuan Hu |
Pubblicazione: | Singapore : , : Springer, , [2021] |
©2021 | |
Edizione: | 1st ed. 2021. |
Descrizione fisica: | 1 online resource (XV, 102 p. 75 illus., 65 illus. in color.) |
Disciplina: | 547.756 |
Soggetto topico: | Peptides - Synthesis |
Cancer - Research | |
Peptides - Biotechnology | |
Chemistry Techniques, Synthetic | |
Peptides - therapeutic use | |
Peptides, Cyclic | |
Biomedical Research | |
Nota di contenuto: | Introduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide. |
Sommario/riassunto: | This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. . |
Titolo autorizzato: | Development of In-Tether Carbon Chiral Center-Induced Helical Peptide |
ISBN: | 981-336-613-3 |
Formato: | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910484381203321 |
Lo trovi qui: | Univ. Federico II |
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