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Titolo: |
Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich
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Pubblicazione: | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
Edizione: | 1st ed. 2014. |
Descrizione fisica: | 1 online resource (441 p.) |
Disciplina: | 572.696 |
Soggetto topico: | Pharmacology |
Biochemistry | |
Proteins | |
Gene therapy | |
Cell physiology | |
Pharmacology/Toxicology | |
Biochemistry, general | |
Protein Structure | |
Gene Therapy | |
Cell Physiology | |
Receptors | |
Persona (resp. second.): | GurevichVsevolod V |
Note generali: | Description based upon print version of record. |
Nota di bibliografia: | Includes bibliographical references and index. |
Nota di contenuto: | Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia. |
Sommario/riassunto: | This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners. |
Titolo autorizzato: | Arrestins ![]() |
ISBN: | 3-642-41199-1 |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910298309403321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |