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Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich



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Titolo: Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich Visualizza cluster
Pubblicazione: Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
Edizione: 1st ed. 2014.
Descrizione fisica: 1 online resource (441 p.)
Disciplina: 572.696
Soggetto topico: Pharmacology
Biochemistry
Proteins 
Gene therapy
Cell physiology
Pharmacology/Toxicology
Biochemistry, general
Protein Structure
Gene Therapy
Cell Physiology
Receptors
Persona (resp. second.): GurevichVsevolod V
Note generali: Description based upon print version of record.
Nota di bibliografia: Includes bibliographical references and index.
Nota di contenuto: Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
Sommario/riassunto: This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
Titolo autorizzato: Arrestins  Visualizza cluster
ISBN: 3-642-41199-1
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910298309403321
Lo trovi qui: Univ. Federico II
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Serie: Handbook of Experimental Pharmacology, . 0171-2004 ; ; 219