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010   $a3-642-41199-1
024 7 $a10.1007/978-3-642-41199-1
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035   $a(DE-He213)978-3-642-41199-1
035   $a(PPN)176115803
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100   $a20131128d2014      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aArrestins - Pharmacology and Therapeutic Potential$b[electronic resource] /$fedited by Vsevolod V. Gurevich
205   $a1st ed. 2014.
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014.
215   $a1 online resource (441 p.)
225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v219
300   $aDescription based upon print version of record.
311   $a3-642-41198-3 
320   $aIncludes bibliographical references and index.
327   $aTherapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
330   $aThis volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
410  0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v219
606   $aPharmacology
606   $aBiochemistry
606   $aProteins 
606   $aGene therapy
606   $aCell physiology
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005
606   $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050
606   $aGene Therapy$3https://scigraph.springernature.com/ontologies/product-market-codes/B12020
606   $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010
606   $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110
615  0$aPharmacology.
615  0$aBiochemistry.
615  0$aProteins .
615  0$aGene therapy.
615  0$aCell physiology.
615 14$aPharmacology/Toxicology.
615 24$aBiochemistry, general.
615 24$aProtein Structure.
615 24$aGene Therapy.
615 24$aCell Physiology.
615 24$aReceptors.
676   $a572.696
702   $aGurevich$b Vsevolod V$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298309403321
996   $aArrestins$91078336
997   $aUNINA