04151nam 22007455 450 991029830940332120200707005025.03-642-41199-110.1007/978-3-642-41199-1(CKB)3710000000074934(EBL)1593194(SSID)ssj0001066356(PQKBManifestationID)11650319(PQKBTitleCode)TC0001066356(PQKBWorkID)11067179(PQKB)11258681(MiAaPQ)EBC1593194(DE-He213)978-3-642-41199-1(PPN)176115803(EXLCZ)99371000000007493420131128d2014 u| 0engur|n|---|||||txtccrArrestins - Pharmacology and Therapeutic Potential /edited by Vsevolod V. Gurevich1st ed. 2014.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2014.1 online resource (441 p.)Handbook of Experimental Pharmacology,0171-2004 ;219Description based upon print version of record.3-642-41198-3 Includes bibliographical references and index.Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.Handbook of Experimental Pharmacology,0171-2004 ;219PharmacologyBiochemistryProteins Gene therapyCell physiologyPharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Protein Structurehttps://scigraph.springernature.com/ontologies/product-market-codes/L14050Gene Therapyhttps://scigraph.springernature.com/ontologies/product-market-codes/B12020Cell Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L33010Receptorshttps://scigraph.springernature.com/ontologies/product-market-codes/L14110Pharmacology.Biochemistry.Proteins .Gene therapy.Cell physiology.Pharmacology/Toxicology.Biochemistry, general.Protein Structure.Gene Therapy.Cell Physiology.Receptors.572.696Gurevich Vsevolod Vedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298309403321Arrestins1078336UNINA