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[null,"1.","Record Nr.",null,"UNINA9910298309403321"]
[null,null,"Titolo",null,"Arrestins - Pharmacology and Therapeutic Potential / / edited by Vsevolod V. Gurevich"]
[null,null,"Pubbl/distr/stampa",null,"Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014"]
[null,null,"ISBN",null,"3-642-41199-1"]
[null,null,"Edizione",null,"[1st ed. 2014.]"]
[null,null,"Descrizione fisica",null,"1 online resource (441 p.)"]
[null,null,"Collana",null,"Handbook of Experimental Pharmacology, , 0171-2004 ; ; 219"]
[null,null,"Disciplina",null,"572.696"]
[null,null,"Soggetti",null,"Pharmacology"]
[{"$nulls":4},"Biochemistry"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Gene therapy"]
[{"$nulls":4},"Cell physiology"]
[{"$nulls":4},"Pharmacology/Toxicology"]
[{"$nulls":4},"Biochemistry, general"]
[{"$nulls":4},"Protein Structure"]
[{"$nulls":4},"Gene Therapy"]
[{"$nulls":4},"Cell Physiology"]
[{"$nulls":4},"Receptors"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- "]
[{"$nulls":4},"Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia."]
[null,null,null,"Sommario/riassunto","This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners."]