X-ray phase-contrast tomography : underlying physics and developments for breast imaging / / Luca Brombal

• Autore: Brombal Luca
• Pubblicazione: Cham, Switzerland : , : Springer, , [2020]; ©2020
• Edizione: 1st ed. 2020.
• Descrizione fisica: 1 online resource (XIII, 140 p. 68 illus., 53 illus. in color.)
• Disciplina: 616.9944906
• Soggetto topico: Breast - Cancer - Tomography; Breast - Cancer - Diagnosis; Breast Neoplasms - diagnostic imaging
• Nota di contenuto: Introduction -- Physics of Propagation-based X-ray Tomography -- Propagation-based Breast CT and SYRMA-3D Project -- Detector and Pre-processing -- Experimental Optimization of Propagation-based BCT -- Three-Dimensional Imaging: A Clinically Oriented Focus -- Do We Need Clinical Applications in Synchrotrons? -- Conclusions.
• Sommario/riassunto: X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals. .
• Titolo autorizzato: X-ray phase-contrast tomography
• ISBN: 3-030-60433-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910427669303321
• Lo trovi qui: Univ. Federico II
• Serie: Springer theses.