03966nam 22006975 450 991042766930332120251202165757.03-030-60433-010.1007/978-3-030-60433-2(CKB)4100000011586164(DE-He213)978-3-030-60433-2(MiAaPQ)EBC6404880(PPN)25250819X(MiAaPQ)EBC29093094(EXLCZ)99410000001158616420201116d2020 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierX-Ray Phase-Contrast Tomography Underlying Physics and Developments for Breast Imaging /by Luca Brombal1st ed. 2020.Cham :Springer International Publishing :Imprint: Springer,2020.1 online resource (XIII, 140 p. 68 illus., 53 illus. in color.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-50613-030-60432-2 Introduction -- Physics of Propagation-based X-ray Tomography -- Propagation-based Breast CT and SYRMA-3D Project -- Detector and Pre-processing -- Experimental Optimization of Propagation-based BCT -- Three-Dimensional Imaging: A Clinically Oriented Focus -- Do We Need Clinical Applications in Synchrotrons? -- Conclusions.X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals. .Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061Medical physicsCancerMedical screeningRadiography, MedicalSynchrotronsCancerImagingMedical PhysicsCancer ScreeningRadiographySynchrotron TechniquesCancer ImagingMedical physics.Cancer.Medical screening.Radiography, Medical.Synchrotrons.CancerImaging.Medical Physics.Cancer Screening.Radiography.Synchrotron Techniques.Cancer Imaging.616.9944906Brombal Luca928817MiAaPQMiAaPQMiAaPQBOOK9910427669303321X-ray phase-contrast tomography2087450UNINA