LEADER 03966nam 22006975 450 001 9910427669303321 005 20251202165757.0 010 $a3-030-60433-0 024 7 $a10.1007/978-3-030-60433-2 035 $a(CKB)4100000011586164 035 $a(DE-He213)978-3-030-60433-2 035 $a(MiAaPQ)EBC6404880 035 $a(PPN)25250819X 035 $a(MiAaPQ)EBC29093094 035 $a(EXLCZ)994100000011586164 100 $a20201116d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aX-Ray Phase-Contrast Tomography $eUnderlying Physics and Developments for Breast Imaging /$fby Luca Brombal 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XIII, 140 p. 68 illus., 53 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 311 08$a3-030-60432-2 327 $aIntroduction -- Physics of Propagation-based X-ray Tomography -- Propagation-based Breast CT and SYRMA-3D Project -- Detector and Pre-processing -- Experimental Optimization of Propagation-based BCT -- Three-Dimensional Imaging: A Clinically Oriented Focus -- Do We Need Clinical Applications in Synchrotrons? -- Conclusions. 330 $aX-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals. . 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 606 $aMedical physics 606 $aCancer 606 $aMedical screening 606 $aRadiography, Medical 606 $aSynchrotrons 606 $aCancer$xImaging 606 $aMedical Physics 606 $aCancer Screening 606 $aRadiography 606 $aSynchrotron Techniques 606 $aCancer Imaging 615 0$aMedical physics. 615 0$aCancer. 615 0$aMedical screening. 615 0$aRadiography, Medical. 615 0$aSynchrotrons. 615 0$aCancer$xImaging. 615 14$aMedical Physics. 615 24$aCancer Screening. 615 24$aRadiography. 615 24$aSynchrotron Techniques. 615 24$aCancer Imaging. 676 $a616.9944906 700 $aBrombal$b Luca$0928817 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910427669303321 996 $aX-ray phase-contrast tomography$92087450 997 $aUNINA