Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

• Autore: Boverhof Darrell R
• Pubblicazione: Hoboken : , : Wiley, , 2011
• Edizione: First edition.
• Descrizione fisica: 1 online resource (402 pages)
• Disciplina: 616.042; 616/.042
• Soggetto topico: Genetic toxicology; Health risk assessment; Risk Assessment; Toxicity testing; Toxicogenetics; Toxicology; Pharmacogenetics; Risk; Risk Management; Epidemiologic Measurements; Organization and Administration; Pharmacology; Probability; Genetics; Public Health; Health Occupations; Statistics as Topic; Biological Science Disciplines; Biology; Health Services Administration; Environment and Public Health; Natural Science Disciplines; Health Care; Health Care Evaluation Mechanisms; Epidemiologic Methods; Quality of Health Care; Investigative Techniques; Health Care Quality, Access, and Evaluation; Health & Biological Sciences; Toxicology & Public Health
• Altri autori: GollapudiB. Bhaskar
• Note generali: Description based upon print version of record.
• Nota di contenuto: Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity ; 8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan ; 16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index
• Sommario/riassunto: This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how tox
• Titolo autorizzato: Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
• ISBN: 1-283-23966-3; 9786613239662; 1-118-00104-4; 1-118-00103-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910824275603321
• Lo trovi qui: Univ. Federico II