06241nam 22014533u 450 991082427560332120240520184221.01-283-23966-397866132396621-118-00104-41-118-00103-6(CKB)2550000000045637(EBL)693202(OCoLC)746321023(SSID)ssj0000534058(PQKBManifestationID)12215780(PQKBTitleCode)TC0000534058(PQKBWorkID)10510847(PQKB)11321286(MiAaPQ)EBC693202(EXLCZ)99255000000004563720131014d2011|||| u|| |engur|n|---|||||txtrdacontentcrdamediacrrdacarrierApplications of Toxicogenomics in Safety Evaluation and Risk AssessmentFirst edition.Hoboken :Wiley,2011.1 online resource (402 pages)Description based upon print version of record.0-470-44982-9 Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; IndexThis book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxGenetic toxicologyGenetic toxicologyHealth risk assessmentHealth risk assessmentRisk AssessmentToxicity testingToxicity testingToxicogeneticsGenetic toxicologyToxicity testingHealth risk assessmentToxicologyPharmacogeneticsRiskRisk ManagementEpidemiologic MeasurementsOrganization and AdministrationPharmacologyProbabilityGeneticsPublic HealthHealth OccupationsStatistics as TopicBiological Science DisciplinesBiologyHealth Services AdministrationEnvironment and Public HealthNatural Science DisciplinesHealth CareHealth Care Evaluation MechanismsEpidemiologic MethodsQuality of Health CareInvestigative TechniquesHealth Care Quality, Access, and EvaluationRisk AssessmentToxicogeneticsHealth & Biological SciencesHILCCToxicology & Public HealthHILCCGenetic toxicology.Genetic toxicology.Health risk assessment.Health risk assessment.Risk Assessment.Toxicity testing.Toxicity testing.Toxicogenetics.Genetic toxicologyToxicity testingHealth risk assessmentToxicologyPharmacogeneticsRiskRisk ManagementEpidemiologic MeasurementsOrganization and AdministrationPharmacologyProbabilityGeneticsPublic HealthHealth OccupationsStatistics as TopicBiological Science DisciplinesBiologyHealth Services AdministrationEnvironment and Public HealthNatural Science DisciplinesHealth CareHealth Care Evaluation MechanismsEpidemiologic MethodsQuality of Health CareInvestigative TechniquesHealth Care Quality, Access, and EvaluationRisk AssessmentToxicogeneticsHealth & Biological SciencesToxicology & Public Health616.042616/.042Boverhof Darrell R1645508Gollapudi B. Bhaskar1645509AU-PeELAU-PeELAU-PeELBOOK9910824275603321Applications of Toxicogenomics in Safety Evaluation and Risk Assessment3992010UNINA