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Record Nr. |
UNINA9910824275603321 |
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Autore |
Boverhof Darrell R |
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Titolo |
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment |
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Pubbl/distr/stampa |
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Hoboken : , : Wiley, , 2011 |
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ISBN |
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1-283-23966-3 |
9786613239662 |
1-118-00104-4 |
1-118-00103-6 |
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Edizione |
[First edition.] |
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Descrizione fisica |
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1 online resource (402 pages) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Genetic toxicology |
Health risk assessment |
Risk Assessment |
Toxicity testing |
Toxicogenetics |
Toxicology |
Pharmacogenetics |
Risk |
Risk Management |
Epidemiologic Measurements |
Organization and Administration |
Pharmacology |
Probability |
Genetics |
Public Health |
Health Occupations |
Statistics as Topic |
Biological Science Disciplines |
Biology |
Health Services Administration |
Environment and Public Health |
Natural Science Disciplines |
Health Care |
Health Care Evaluation Mechanisms |
Epidemiologic Methods |
Quality of Health Care |
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Investigative Techniques |
Health Care Quality, Access, and Evaluation |
Health & Biological Sciences |
Toxicology & Public Health |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity |
8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan |
16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index |
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Sommario/riassunto |
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This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how tox |
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