LEADER 06264nam 22014533u 450 001 9910824275603321 005 20240520184221.0 010 $a1-283-23966-3 010 $a9786613239662 010 $a1-118-00104-4 010 $a1-118-00103-6 035 $a(CKB)2550000000045637 035 $a(EBL)693202 035 $a(OCoLC)746321023 035 $a(SSID)ssj0000534058 035 $a(PQKBManifestationID)12215780 035 $a(PQKBTitleCode)TC0000534058 035 $a(PQKBWorkID)10510847 035 $a(PQKB)11321286 035 $a(MiAaPQ)EBC693202 035 $a(EXLCZ)992550000000045637 100 $a20131014d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aApplications of Toxicogenomics in Safety Evaluation and Risk Assessment$b[electronic resource] 205 $aFirst edition. 210 1$aHoboken :$cWiley,$d2011. 215 $a1 online resource (402 pages) 300 $aDescription based upon print version of record. 311 $a0-470-44982-9 327 $aContents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity 327 $a8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan 327 $a16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index 330 $aThis book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how tox 606 $aGenetic toxicology 606 $aGenetic toxicology 606 $aHealth risk assessment 606 $aHealth risk assessment 606 $aRisk Assessment 606 $aToxicity testing 606 $aToxicity testing 606 $aToxicogenetics 606 $aGenetic toxicology 606 $aToxicity testing 606 $aHealth risk assessment 606 $aToxicology 606 $aPharmacogenetics 606 $aRisk 606 $aRisk Management 606 $aEpidemiologic Measurements 606 $aOrganization and Administration 606 $aPharmacology 606 $aProbability 606 $aGenetics 606 $aPublic Health 606 $aHealth Occupations 606 $aStatistics as Topic 606 $aBiological Science Disciplines 606 $aBiology 606 $aHealth Services Administration 606 $aEnvironment and Public Health 606 $aNatural Science Disciplines 606 $aHealth Care 606 $aHealth Care Evaluation Mechanisms 606 $aEpidemiologic Methods 606 $aQuality of Health Care 606 $aInvestigative Techniques 606 $aHealth Care Quality, Access, and Evaluation 606 $aRisk Assessment 606 $aToxicogenetics 606 $aHealth & Biological Sciences$2HILCC 606 $aToxicology & Public Health$2HILCC 615 4$aGenetic toxicology. 615 4$aGenetic toxicology. 615 4$aHealth risk assessment. 615 4$aHealth risk assessment. 615 4$aRisk Assessment. 615 4$aToxicity testing. 615 4$aToxicity testing. 615 4$aToxicogenetics. 615 0$aGenetic toxicology 615 0$aToxicity testing 615 0$aHealth risk assessment 615 2$aToxicology 615 2$aPharmacogenetics 615 2$aRisk 615 2$aRisk Management 615 2$aEpidemiologic Measurements 615 2$aOrganization and Administration 615 2$aPharmacology 615 2$aProbability 615 2$aGenetics 615 2$aPublic Health 615 2$aHealth Occupations 615 2$aStatistics as Topic 615 2$aBiological Science Disciplines 615 2$aBiology 615 2$aHealth Services Administration 615 2$aEnvironment and Public Health 615 2$aNatural Science Disciplines 615 2$aHealth Care 615 2$aHealth Care Evaluation Mechanisms 615 2$aEpidemiologic Methods 615 2$aQuality of Health Care 615 2$aInvestigative Techniques 615 2$aHealth Care Quality, Access, and Evaluation 615 2$aRisk Assessment 615 2$aToxicogenetics 615 7$aHealth & Biological Sciences 615 7$aToxicology & Public Health 676 $a616.042 676 $a616/.042 700 $aBoverhof$b Darrell R$01645508 701 $aGollapudi$b B. Bhaskar$01645509 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910824275603321 996 $aApplications of Toxicogenomics in Safety Evaluation and Risk Assessment$93992010 997 $aUNINA