The nature and origin of amyloid fibrils / / [editors, Gregory R. Bock (Organizer) and Jamie A. Goode]
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| Titolo: |
The nature and origin of amyloid fibrils / / [editors, Gregory R. Bock (Organizer) and Jamie A. Goode]
|
| Pubblicazione: | Chichester ; ; New York, : Wiley, 1996 |
| Descrizione fisica: | 1 online resource (268 p.) |
| Disciplina: | 612.8/042 |
| Soggetto topico: | Amyloid |
| Amyloid beta-protein | |
| Amyloidosis | |
| Altri autori: |
BockeGregory
GoodeJamie
|
| Note generali: | "Symposium on The nature and origin of amyloid fibrils, held at the Palacio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents. |
| Nota di bibliografia: | Includes bibliographical references and indexes. |
| Nota di contenuto: | THE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteins |
| Alzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion V | |
| FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject index | |
| Sommario/riassunto: | Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved. |
| Titolo autorizzato: | The nature and origin of amyloid fibrils |
| ISBN: | 9786612347979 |
| 9781282347977 | |
| 1282347977 | |
| 9780470514924 | |
| 0470514922 | |
| 9780470514931 | |
| 0470514930 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9911019629303321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Ciba Foundation symposium ; ; 199.