LEADER 01386nas 2200421- 450 001 996321068903316 005 20230124192952.0 011 $a1894-4647 035 $a(OCoLC)900029766 035 $a(CKB)3710000000330280 035 $a(CONSER)--2015235009 035 $a(DE-599)ZDB2845599-X 035 $a(EXLCZ)993710000000330280 100 $a20150113a20139999 |-- - 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNordic journal of science and technology studies 210 1$aTrondheim, Norway :$c[Nordic journal of science and technology studies],$d[2013]- 215 $a1 online resource 300 $a"Published with the support of the Nordic Research Councils for the Humanities and the Social Sciences and the Norwegian University of Science and Technology." 517 1 $aNJSTS 517 1 $aNordic journal 606 $aScience$vPeriodicals 606 $aTechnology$vPeriodicals 606 $aScience$2fast$3(OCoLC)fst01108176 606 $aTechnology$2fast$3(OCoLC)fst01145078 608 $aPeriodicals.$2fast 615 0$aScience 615 0$aTechnology 615 7$aScience. 615 7$aTechnology. 906 $aJOURNAL 912 $a996321068903316 996 $aNordic journal of science and technology studies$91927527 997 $aUNISA LEADER 03693nam 2200685 a 450 001 9911019629303321 005 20200520144314.0 010 $a9786612347979 010 $a9781282347977 010 $a1282347977 010 $a9780470514924 010 $a0470514922 010 $a9780470514931 010 $a0470514930 035 $a(CKB)1000000000377216 035 $a(EBL)470493 035 $a(SSID)ssj0000304052 035 $a(PQKBManifestationID)11275948 035 $a(PQKBTitleCode)TC0000304052 035 $a(PQKBWorkID)10278879 035 $a(PQKB)11530548 035 $a(MiAaPQ)EBC470493 035 $a(OCoLC)181181768 035 $a(Perlego)2784996 035 $a(EXLCZ)991000000000377216 100 $a19960424d1996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe nature and origin of amyloid fibrils /$f[editors, Gregory R. Bock (Organizer) and Jamie A. Goode] 210 $aChichester ;$aNew York $cWiley$d1996 215 $a1 online resource (268 p.) 225 1 $aCiba Foundation symposium ;$v199 300 $a"Symposium on The nature and origin of amyloid fibrils, held at the Palacio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents. 311 08$a9780471963615 311 08$a0471963615 320 $aIncludes bibliographical references and indexes. 327 $aTHE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteins 327 $aAlzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion V 327 $aFAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject index 330 $aAmyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved. 410 0$aCiba Foundation symposium ;$v199. 606 $aAmyloid$vCongresses 606 $aAmyloid beta-protein$vCongresses 606 $aAmyloidosis$vCongresses 615 0$aAmyloid 615 0$aAmyloid beta-protein 615 0$aAmyloidosis 676 $a612.8/042 701 $aBocke$b Gregory$01841001 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019629303321 996 $aThe nature and origin of amyloid fibrils$94420593 997 $aUNINA