03693nam 2200685 a 450 991101962930332120200520144314.09786612347979978128234797712823479779780470514924047051492297804705149310470514930(CKB)1000000000377216(EBL)470493(SSID)ssj0000304052(PQKBManifestationID)11275948(PQKBTitleCode)TC0000304052(PQKBWorkID)10278879(PQKB)11530548(MiAaPQ)EBC470493(OCoLC)181181768(Perlego)2784996(EXLCZ)99100000000037721619960424d1996 uy 0engur|n|---|||||txtccrThe nature and origin of amyloid fibrils /[editors, Gregory R. Bock (Organizer) and Jamie A. Goode]Chichester ;New York Wiley19961 online resource (268 p.)Ciba Foundation symposium ;199"Symposium on The nature and origin of amyloid fibrils, held at the Palacio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents.9780471963615 0471963615 Includes bibliographical references and indexes.THE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteinsAlzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion VFAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject indexAmyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.Ciba Foundation symposium ;199.AmyloidCongressesAmyloid beta-proteinCongressesAmyloidosisCongressesAmyloidAmyloid beta-proteinAmyloidosis612.8/042Bocke Gregory1841001Goode Jamie283336MiAaPQMiAaPQMiAaPQBOOK9911019629303321The nature and origin of amyloid fibrils4420593UNINA