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1. |
Record Nr. |
UNINA990008565250403321 |
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Autore |
Pollock, John L. |
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Titolo |
Contemporary theories of knowledge / John L. Pollock |
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Pubbl/distr/stampa |
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Totowa (New Jersey) : Rowman and Littlefield, 1986 |
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ISBN |
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Descrizione fisica |
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Collana |
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Rowman & Littlefield texts in philosophy |
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Disciplina |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9911019629303321 |
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Titolo |
The nature and origin of amyloid fibrils / / [editors, Gregory R. Bock (Organizer) and Jamie A. Goode] |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 1996 |
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ISBN |
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9786612347979 |
9781282347977 |
1282347977 |
9780470514924 |
0470514922 |
9780470514931 |
0470514930 |
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Descrizione fisica |
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1 online resource (268 p.) |
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Collana |
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Ciba Foundation symposium ; ; 199 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Amyloid |
Amyloid beta-protein |
Amyloidosis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Symposium on The nature and origin of amyloid fibrils, held at the Palacio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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THE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteins |
Alzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion V |
FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject index |
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Sommario/riassunto |
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Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved. |
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