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DNA experimente : spannende experimente im eigenen DNA-Labor / / Ulrich E. Stempel
DNA experimente : spannende experimente im eigenen DNA-Labor / / Ulrich E. Stempel
Autore Stempel Ulrich E.
Pubbl/distr/stampa München, [Germany] : , : Franzis Verlag GmbH, , 2016
Descrizione fisica 1 online resource (161 pages) : illustrations (some color)
Disciplina 572.86
Soggetto topico DNA
ISBN 3-645-25335-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione ger
Record Nr. UNINA-9910155404803321
Stempel Ulrich E.  
München, [Germany] : , : Franzis Verlag GmbH, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
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DNA Helicases and DNA Motor Proteins [[electronic resource] /] / edited by Maria Spies
DNA Helicases and DNA Motor Proteins [[electronic resource] /] / edited by Maria Spies
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Descrizione fisica 1 online resource (307 p.)
Disciplina 572.86
Collana Advances in Experimental Medicine and Biology
Soggetto topico Human genetics
Biochemistry
Cell biology
Medicine
Human Genetics
Biochemistry, general
Cell Biology
Biomedicine, general
ISBN 1-283-86505-X
1-4614-5037-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preface -- Overview: What are DNA helicases? -- Structure and mechanisms of SF1 DNA helicases -- Structure and mechanisms of SF2 DNA helicases -- Structure and mechanisms of hexameric helicases -- Helicases at the replication fork -- DNA helicases associated with genetic instability, cancer and aging -- The Helicase-primase complex as a target for effective herpesvirus antivirals -- RecQ helicases - conserved guardians of genetic integrity -- Roles of DNA helicases in the mediation and rRegulation of homologous recombination -- DNA helicases in NER, BER and MMR -- Roles for helicases as ATP-dependent molecular switches -- The FtsK family of DNA pumps -- ATP dependent chromatin remodelers -- Index.
Record Nr. UNINA-9910437836003321
New York, NY : , : Springer New York : , : Imprint : Springer, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
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DNA interactions with polymers and surfactants [[electronic resource] /] / edited by Rita Dias and Björn Lindman
DNA interactions with polymers and surfactants [[electronic resource] /] / edited by Rita Dias and Björn Lindman
Pubbl/distr/stampa Hoboken, N.J., : John Wiley, c2008
Descrizione fisica 1 online resource (436 p.)
Disciplina 572.8/6
572.86
Altri autori (Persone) LindmanBjörn <1942->
DiasRita
Soggetto topico DNA
Polymers
Surface active agents
ISBN 1-281-28527-7
9786611285272
0-470-28636-9
0-470-28635-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto DNA INTERACTIONS WITH POLYMERS AND SURFACTANTS; CONTENTS; Preface; Contributors; 1 Polyelectrolytes. Physicochemical Aspects and Biological Significance; 1.1 Introduction; 1.2 Polyelectrolytes and Biological Function; 1.3 Electrostatic Interactions; 1.3.1 Ion Distributions and the Poisson-Boltzmann Equation; 1.3.2 Debye-Hückel Theory; 1.4 Solution Properties; 1.5 Flexibility; 1.5.1 The Concept of Persistence Length; 1.5.2 Interactions and the Separation of Length Scales; 1.5.3 Polyelectrolyte Behavior: Electrostatic Persistence Length; 1.5.4 DNA Persistence Length; References
2 Solution Behavior of Nucleic Acids2.1 Biological Function of Nucleic Acids; 2.2 Discovery of DNA; 2.3 Structure of Nucleic Acids; 2.3.1 DNA; 2.3.2 RNA; 2.3.3 Analogues of Nucleic Acids; 2.4 Nuclei Acids Nanostructures; 2.4.1 DNA; 2.4.2 RNA; 2.5 Behavior of DNA in Solution; 2.5.1 Ionization Equilibrium; 2.5.2 Flexibility of Nucleic Acids; 2.6 Melting of Double-Stranded DNA; 2.6.1 Effect of Base Composition; 2.6.2 Effect of Ionic Strength; 2.6.3 Effect of pH; 2.6.4 Dependence on DNA Chain Length; 2.6.5 Dependence on DNA Concentration; Acknowledgments; References
3 Single DNA Molecules: Compaction and Decompaction3.1 Introduction; 3.2 Condensation and Compaction of DNA by Surfactants; 3.2.1 Linear DNA Condensation/Compaction by Positively Charged Surfactants; 3.2.2 Compaction of Plasmid DNA with Surfactants; 3.2.3 Non-ionic Surfactants; 3.2.4 Zwitterionic Surfactants; 3.2.5 Decompaction of DNA-Surfactant Complex; 3.3 DNA Condensation by Cationic Liposomes; 3.4 DNA Compaction and Decompaction by Multivalent Cations; 3.5 DNA Compaction by Polycations; 3.6 Compaction of DNA in a Crowded Environment of Neutral Polymer; 3.7 Conclusion; References
4 Interaction of DNA with Surfactants in Solution4.1 Introduction; 4.1.1 Surfactants; 4.1.2 Polymer-Surfactant Interactions; 4.1.3 Polyelectrolyte-Oppositely Charged Surfactant Interactions; 4.1.4 DNA-Surfactant Interactions; 4.2 DNA-Cationic Surfactant Interactions; 4.2.1 Solution Behavior; 4.2.2 Effect of the Surfactant Chain Length; 4.2.3 Effect of the Surfactant Head-group; 4.2.4 Structure of DNA-Surfactant Complexes; 4.2.5 DNA Is an Amphiphilic Polyelectrolyte; 4.3 DNA Covalent Gels and Their Interaction with Surfactants; 4.4 Applications; 4.4.1 Control of DNA Compaction/Decompaction
4.4.2 Purification4.4.3 Gene Transfection; Acknowledgments; References; 5 Interaction of DNA with Cationic Polymers; 5.1 Introduction; 5.2 Theory of DNA Interacting with Polycations; 5.2.1 Manning Condensation; 5.2.2 Counterion Release; 5.2.3 Short-Range Attractive Force due to Ion Correlations; 5.2.4 Phase Diagrams of Condensed DNA-Polycation Phases; 5.2.5 Finite-Size Aggregates; 5.3 Condensation of DNA, Phase Diagram, and Structure; 5.3.1 Short Polycations and Multivalent Cations; 5.3.2 Long Polycations and Basic Proteins; 5.4 Formation of Polycation-DNA Complexes: Polyplexes
5.5 DNA-Nanoparticles for Gene Delivery
Record Nr. UNINA-9910145422003321
Hoboken, N.J., : John Wiley, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
DNA interactions with polymers and surfactants [[electronic resource] /] / edited by Rita Dias and Björn Lindman
DNA interactions with polymers and surfactants [[electronic resource] /] / edited by Rita Dias and Björn Lindman
Pubbl/distr/stampa Hoboken, N.J., : John Wiley, c2008
Descrizione fisica 1 online resource (436 p.)
Disciplina 572.8/6
572.86
Altri autori (Persone) LindmanBjörn <1942->
DiasRita
Soggetto topico DNA
Polymers
Surface active agents
ISBN 1-281-28527-7
9786611285272
0-470-28636-9
0-470-28635-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto DNA INTERACTIONS WITH POLYMERS AND SURFACTANTS; CONTENTS; Preface; Contributors; 1 Polyelectrolytes. Physicochemical Aspects and Biological Significance; 1.1 Introduction; 1.2 Polyelectrolytes and Biological Function; 1.3 Electrostatic Interactions; 1.3.1 Ion Distributions and the Poisson-Boltzmann Equation; 1.3.2 Debye-Hückel Theory; 1.4 Solution Properties; 1.5 Flexibility; 1.5.1 The Concept of Persistence Length; 1.5.2 Interactions and the Separation of Length Scales; 1.5.3 Polyelectrolyte Behavior: Electrostatic Persistence Length; 1.5.4 DNA Persistence Length; References
2 Solution Behavior of Nucleic Acids2.1 Biological Function of Nucleic Acids; 2.2 Discovery of DNA; 2.3 Structure of Nucleic Acids; 2.3.1 DNA; 2.3.2 RNA; 2.3.3 Analogues of Nucleic Acids; 2.4 Nuclei Acids Nanostructures; 2.4.1 DNA; 2.4.2 RNA; 2.5 Behavior of DNA in Solution; 2.5.1 Ionization Equilibrium; 2.5.2 Flexibility of Nucleic Acids; 2.6 Melting of Double-Stranded DNA; 2.6.1 Effect of Base Composition; 2.6.2 Effect of Ionic Strength; 2.6.3 Effect of pH; 2.6.4 Dependence on DNA Chain Length; 2.6.5 Dependence on DNA Concentration; Acknowledgments; References
3 Single DNA Molecules: Compaction and Decompaction3.1 Introduction; 3.2 Condensation and Compaction of DNA by Surfactants; 3.2.1 Linear DNA Condensation/Compaction by Positively Charged Surfactants; 3.2.2 Compaction of Plasmid DNA with Surfactants; 3.2.3 Non-ionic Surfactants; 3.2.4 Zwitterionic Surfactants; 3.2.5 Decompaction of DNA-Surfactant Complex; 3.3 DNA Condensation by Cationic Liposomes; 3.4 DNA Compaction and Decompaction by Multivalent Cations; 3.5 DNA Compaction by Polycations; 3.6 Compaction of DNA in a Crowded Environment of Neutral Polymer; 3.7 Conclusion; References
4 Interaction of DNA with Surfactants in Solution4.1 Introduction; 4.1.1 Surfactants; 4.1.2 Polymer-Surfactant Interactions; 4.1.3 Polyelectrolyte-Oppositely Charged Surfactant Interactions; 4.1.4 DNA-Surfactant Interactions; 4.2 DNA-Cationic Surfactant Interactions; 4.2.1 Solution Behavior; 4.2.2 Effect of the Surfactant Chain Length; 4.2.3 Effect of the Surfactant Head-group; 4.2.4 Structure of DNA-Surfactant Complexes; 4.2.5 DNA Is an Amphiphilic Polyelectrolyte; 4.3 DNA Covalent Gels and Their Interaction with Surfactants; 4.4 Applications; 4.4.1 Control of DNA Compaction/Decompaction
4.4.2 Purification4.4.3 Gene Transfection; Acknowledgments; References; 5 Interaction of DNA with Cationic Polymers; 5.1 Introduction; 5.2 Theory of DNA Interacting with Polycations; 5.2.1 Manning Condensation; 5.2.2 Counterion Release; 5.2.3 Short-Range Attractive Force due to Ion Correlations; 5.2.4 Phase Diagrams of Condensed DNA-Polycation Phases; 5.2.5 Finite-Size Aggregates; 5.3 Condensation of DNA, Phase Diagram, and Structure; 5.3.1 Short Polycations and Multivalent Cations; 5.3.2 Long Polycations and Basic Proteins; 5.4 Formation of Polycation-DNA Complexes: Polyplexes
5.5 DNA-Nanoparticles for Gene Delivery
Record Nr. UNINA-9910829913603321
Hoboken, N.J., : John Wiley, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
DNA interactions with polymers and surfactants [[electronic resource] /] / edited by Rita Dias and Björn Lindman
DNA interactions with polymers and surfactants [[electronic resource] /] / edited by Rita Dias and Björn Lindman
Pubbl/distr/stampa Hoboken, N.J., : John Wiley, c2008
Descrizione fisica 1 online resource (436 p.)
Disciplina 572.8/6
572.86
Altri autori (Persone) LindmanBjörn <1942->
DiasRita
Soggetto topico DNA
Polymers
Surface active agents
ISBN 1-281-28527-7
9786611285272
0-470-28636-9
0-470-28635-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto DNA INTERACTIONS WITH POLYMERS AND SURFACTANTS; CONTENTS; Preface; Contributors; 1 Polyelectrolytes. Physicochemical Aspects and Biological Significance; 1.1 Introduction; 1.2 Polyelectrolytes and Biological Function; 1.3 Electrostatic Interactions; 1.3.1 Ion Distributions and the Poisson-Boltzmann Equation; 1.3.2 Debye-Hückel Theory; 1.4 Solution Properties; 1.5 Flexibility; 1.5.1 The Concept of Persistence Length; 1.5.2 Interactions and the Separation of Length Scales; 1.5.3 Polyelectrolyte Behavior: Electrostatic Persistence Length; 1.5.4 DNA Persistence Length; References
2 Solution Behavior of Nucleic Acids2.1 Biological Function of Nucleic Acids; 2.2 Discovery of DNA; 2.3 Structure of Nucleic Acids; 2.3.1 DNA; 2.3.2 RNA; 2.3.3 Analogues of Nucleic Acids; 2.4 Nuclei Acids Nanostructures; 2.4.1 DNA; 2.4.2 RNA; 2.5 Behavior of DNA in Solution; 2.5.1 Ionization Equilibrium; 2.5.2 Flexibility of Nucleic Acids; 2.6 Melting of Double-Stranded DNA; 2.6.1 Effect of Base Composition; 2.6.2 Effect of Ionic Strength; 2.6.3 Effect of pH; 2.6.4 Dependence on DNA Chain Length; 2.6.5 Dependence on DNA Concentration; Acknowledgments; References
3 Single DNA Molecules: Compaction and Decompaction3.1 Introduction; 3.2 Condensation and Compaction of DNA by Surfactants; 3.2.1 Linear DNA Condensation/Compaction by Positively Charged Surfactants; 3.2.2 Compaction of Plasmid DNA with Surfactants; 3.2.3 Non-ionic Surfactants; 3.2.4 Zwitterionic Surfactants; 3.2.5 Decompaction of DNA-Surfactant Complex; 3.3 DNA Condensation by Cationic Liposomes; 3.4 DNA Compaction and Decompaction by Multivalent Cations; 3.5 DNA Compaction by Polycations; 3.6 Compaction of DNA in a Crowded Environment of Neutral Polymer; 3.7 Conclusion; References
4 Interaction of DNA with Surfactants in Solution4.1 Introduction; 4.1.1 Surfactants; 4.1.2 Polymer-Surfactant Interactions; 4.1.3 Polyelectrolyte-Oppositely Charged Surfactant Interactions; 4.1.4 DNA-Surfactant Interactions; 4.2 DNA-Cationic Surfactant Interactions; 4.2.1 Solution Behavior; 4.2.2 Effect of the Surfactant Chain Length; 4.2.3 Effect of the Surfactant Head-group; 4.2.4 Structure of DNA-Surfactant Complexes; 4.2.5 DNA Is an Amphiphilic Polyelectrolyte; 4.3 DNA Covalent Gels and Their Interaction with Surfactants; 4.4 Applications; 4.4.1 Control of DNA Compaction/Decompaction
4.4.2 Purification4.4.3 Gene Transfection; Acknowledgments; References; 5 Interaction of DNA with Cationic Polymers; 5.1 Introduction; 5.2 Theory of DNA Interacting with Polycations; 5.2.1 Manning Condensation; 5.2.2 Counterion Release; 5.2.3 Short-Range Attractive Force due to Ion Correlations; 5.2.4 Phase Diagrams of Condensed DNA-Polycation Phases; 5.2.5 Finite-Size Aggregates; 5.3 Condensation of DNA, Phase Diagram, and Structure; 5.3.1 Short Polycations and Multivalent Cations; 5.3.2 Long Polycations and Basic Proteins; 5.4 Formation of Polycation-DNA Complexes: Polyplexes
5.5 DNA-Nanoparticles for Gene Delivery
Record Nr. UNINA-9910841779603321
Hoboken, N.J., : John Wiley, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
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DNA markers : protocols, applications, and overviews / edited by Gustavo Caetano-Anollés, Peter M. Gresshoff
DNA markers : protocols, applications, and overviews / edited by Gustavo Caetano-Anollés, Peter M. Gresshoff
Pubbl/distr/stampa New York, : Wiley, 1997
Descrizione fisica XIV, 364 p. : ill. ; 23 cm.
Disciplina 572.86(Acido desossiribonucleico. DNA. Geni e genomi)
ISBN 04-7116-067-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNICAMPANIA-SUN0016939
New York, : Wiley, 1997
Materiale a stampa
Lo trovi qui: Univ. Vanvitelli
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DNA markers : protocols, applications, and overviews / edited by Gustavo Caetano-Anollés, Peter M. Gresshoff
DNA markers : protocols, applications, and overviews / edited by Gustavo Caetano-Anollés, Peter M. Gresshoff
Pubbl/distr/stampa New York, : Wiley, 1997
Descrizione fisica XIV, 364 p. : ill. ; 23 cm
Disciplina 572.86(Acido desossiribonucleico. DNA. Geni e genomi)
ISBN 04-7116-067-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNICAMPANIA-VAN0016939
New York, : Wiley, 1997
Materiale a stampa
Lo trovi qui: Univ. Vanvitelli
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DNA methylation mechanism / / edited by Metin Budak and Mustafa Yıldız
DNA methylation mechanism / / edited by Metin Budak and Mustafa Yıldız
Pubbl/distr/stampa London, United Kingdom : , : IntechOpen, , [2020]
Descrizione fisica 1 online resource (174 pages) : illustrations
Disciplina 572.86
Collana Biochemistry
Soggetto topico DNA
ISBN 1-83880-818-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910409743403321
London, United Kingdom : , : IntechOpen, , [2020]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
DNA methyltransferases - role and function / / Albert Jeltsch and Renata Z. Jurkowska, editors
DNA methyltransferases - role and function / / Albert Jeltsch and Renata Z. Jurkowska, editors
Edizione [Second edition.]
Pubbl/distr/stampa Cham, Switzerland : , : Springer, , [2022]
Descrizione fisica 1 online resource (562 pages)
Disciplina 572.86
Collana Advances in experimental medicine and biology
Soggetto topico DNA
Methyltransferases
ISBN 3-031-11454-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Preface -- Contents -- About the Editors -- 1: Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges -- 1.1 Discovery of DNA Methylation -- 1.2 Discovery and Early Work on DNA MTases -- 1.3 DNA MTases Contain Conserved Amino Acids Sequence Motifs -- 1.4 Structure and Mechanism of DNA MTases -- 1.5 Molecular Evolution of MTases -- 1.6 Early Views on the Biological Role of DNA Methylation -- 1.7 Genetic Studies on DNMTs in Mammals -- 1.8 Structure, Function, and Regulation of Mammalian DNA MTases -- 1.9 Discovery of TET Enzymes -- 1.10 Methods for Site-Specific Detection of DNA Methylation -- 1.11 DNA MTases and Bacterial Epigenetics -- 1.12 Role of DNA Methylation in Cancer -- 1.13 Application of MTases in Artificial Epigenetic Systems -- 1.14 Conclusions and Outlook -- References -- 2: DNA Methylation in Prokaryotes -- 2.1 Introduction -- 2.2 CcrM Methylation -- 2.3 Dam Methylation -- 2.3.1 Role of Dam Methylation in DNA Mismatch Repair -- 2.3.2 Control of Chromosome Replication by Dam Methylation -- 2.3.3 Transcriptional Control by Dam Methylation -- 2.3.3.1 Temporal Regulation of Gene Expression by Dam Methylation -- 2.3.3.2 Regulation of Bistability by Dam Methylation -- 2.4 Phase Variable DNA Adenine Methylation -- 2.5 Additional Examples of DNA Adenine Methylation -- 2.6 C5-Methylcytosine -- 2.7 N4-Methylcytosine -- 2.8 Biomedical and Biotechnological Applications of Dam Methylation -- References -- 3: Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- 3.1 DNA Methylation and Methyltransferases in Mammals -- 3.2 Enzymes Responsible for the Establishment of DNA Methylation Patterns -- 3.2.1 PWWP Domain -- 3.2.2 ADD Domain -- 3.2.3 Catalytic Domain -- 3.2.4 Functions of Other Regions.
3.2.5 Factors That Guide Dnmt3 to the Regions to Be Methylated -- 3.2.6 Correlation Between de novo DNA Methylation and Histone Modifications -- 3.3 Enzymes Responsible for the Maintenance of DNA Methylation Patterns -- 3.3.1 NTD -- 3.3.2 RFTS Domain -- 3.3.3 CXXC -- 3.3.4 Two BAH Domains -- 3.3.5 Catalytic Domain -- 3.4 Cross-Talk Between De Novo-Type and Maintenance-Type DNA Methyltransferases -- 3.5 Conclusions and Perspective -- References -- 4: Enzymology of Mammalian DNA Methyltransferases -- 4.1 Introduction -- 4.2 General Features of Mammalian DNMTs -- 4.2.1 Structure and Domain Composition of Mammalian DNMTs -- 4.2.2 Catalytic Mechanism of C5-MTases -- 4.2.3 Regulation and Targeting of DNMTs -- 4.3 Structure, Function, and Mechanism of DNMT1 -- 4.3.1 Domain Composition of DNMT1 -- 4.3.2 Structures of DNMT1 and Allosteric Regulation -- 4.3.3 Specificity of DNMT1 -- 4.3.4 Processivity of DNMT1 -- 4.3.5 Allosteric Regulation and Targeting of DNMT1 -- 4.3.5.1 The DNMT1-PCNA Interaction -- 4.3.5.2 The DNMT1-UHRF1 Interaction -- 4.3.5.3 Binding of the DNMT1-RFTD to Ubiquitinated H3 Tails -- 4.3.5.4 Binding of DNMT1 to Heterochromatic Chromatin Marks -- 4.3.5.5 Regulation of Activity and Specificity of DNMT1 by Nucleic Acid Binding -- 4.3.6 PTMs of DNMT1 -- 4.3.6.1 Phosphorylation of DNMT1 -- 4.3.6.2 Acetylation and Ubiquitination of DNMT1 -- 4.3.6.3 Lysine Methylation of DNMT1 -- 4.4 Structure, Function, and Mechanism of DNMT3 Enzymes -- 4.4.1 Domain Composition of DNMT3 Proteins -- 4.4.2 Structures of DNMT3A and DNMT3B -- 4.4.3 Allosteric Regulation of DNMT3A -- 4.4.4 Specificity of DNMT3 Enzymes -- 4.4.5 Kinetic Mechanism of DNMT3 Enzymes -- 4.4.6 Oligomerization of DNMT3 Enzymes -- 4.4.6.1 Protein Multimerization of DNMT3 Enzymes -- 4.4.6.2 Multimerization of DNMT3A and DNMT3A/DNMT3L on DNA -- 4.4.7 Direct Chromatin Interaction of DNMT3 Enzymes.
4.4.7.1 Binding of the DNMT3 ADD Domain to H3 Tails -- 4.4.7.2 Binding of DNMT3 PWWP Domain to H3 Methylated at K36 -- 4.4.7.3 H2AK119ub Binding of DNMT3A1 -- 4.4.8 Interaction Partners of DNMT3s -- 4.4.8.1 DNMT3A/DNMT3L Interaction -- 4.4.8.2 Interaction of DNMT3A with MeCP2 -- 4.4.8.3 Other DNMT3A Interacting Proteins -- 4.4.9 Phosphorylation of DNMT3A -- 4.4.10 Binding of Regulatory DNA and RNA to DNMT3 Enzymes -- 4.5 Outlook -- References -- 5: Genetic Studies on Mammalian DNA Methyltransferases -- 5.1 Distinct Roles of Dnmt1 and Dnmt3 Families in DNA Methylation -- 5.1.1 Dnmt1: The Maintenance DNA Methyltransferase -- 5.1.2 Dnmt3 Family: Key Components of De Novo Methylation Machinery -- 5.1.3 Uhrf1: A Major Regulator of Maintenance DNA Methylation -- 5.2 Dnmts in Embryonic Development and Cellular Differentiation -- 5.2.1 Roles of Dnmts in Embryonic Development -- 5.2.2 Roles of Dnmts in Cellular Differentiation and Maintenance of Cell Identity. -- 5.2.3 DNMT Mutations in Human Diseases -- 5.3 Dnmts in Genomic Imprinting -- 5.3.1 Establishment of DNA Methylation Imprints during Gametogenesis -- 5.3.2 Maintenance of DNA Methylation Imprints during Development -- 5.3.3 Erasure of DNA Methylation Imprints in Primordial Germ Cells -- 5.3.4 Noncanonical Genomic Imprinting -- 5.4 Concluding Remarks -- References -- 6: Structure and Mechanism of Plant DNA Methyltransferases -- 6.1 Introduction -- 6.2 Structure and Mechanism of Plant DNA MTases -- 6.2.1 Structural Mechanism of the Maintenance of CHG Methylation in Plants -- 6.2.1.1 Overview of Plant CHG DNA Methylation -- 6.2.1.2 Structure and Mechanism of CMT3 -- 6.2.1.3 Structure and Mechanism of KRYPTONITE -- 6.2.2 Mechanism of CMT2-Mediated CHH Methylation -- 6.2.3 RNA-Directed DNA Methylation (RdDM) -- 6.2.3.1 Overview of RdDM -- 6.2.3.2 Structure and Mechanism of DRM2.
6.2.4 Potential Mechanism of MET1 in CG Methylation Maintenance -- 6.3 Conclusion and Perspective -- References -- 7: DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics -- 7.1 Introduction -- 7.2 Genotype to Phenotype -- 7.3 The Epigenetic Control of Gene Expression -- 7.4 DNA Methylation -- 7.4.1 Conserved and Non-Conserved Features of DNA Methylation Enzymology in Animals -- 7.4.2 DNMTs and Establishing DNA Methylation Patterns in the Honey Bee -- 7.4.3 How do TET Enzymes Contribute to Gene Regulation in the Honey Bees and Other Insects? -- 7.4.4 DNA Methylation Patterns Across Invertebrates -- 7.4.5 Does Gene Body Methylation Direct Gene Expression in Insects? -- 7.5 Conclusion -- References -- 8: N6-methyladenine: A Rare and Dynamic DNA Mark -- 8.1 Introduction -- 8.2 Types of DNA Modifications -- 8.3 Discovery of 6mA in Various Eukaryotes -- 8.4 Abundance of 6mA -- 8.5 Methods of Detecting 6mA -- 8.6 6mA Regulating Enzymes -- 8.6.1 DNA Methyltransferases -- 8.6.2 Mechanism of 6mA Methyltransferases -- 8.7 DNA Adenine Demethylation -- 8.8 6mA Binding Proteins -- 8.9 Biological Functions of 6mA -- 8.9.1 Effects of Adenine Methylation on DNA Structure -- 8.9.2 Restriction-Modification Systems -- 8.9.3 DNA Damage Control -- 8.9.4 Effect on Transcription -- 8.9.5 Nucleosome Positioning -- 8.9.6 Cell Cycle Regulation -- 8.9.7 Transgenerational Inheritance -- 8.10 Conclusions and Future Directions -- References -- 9: Pathways of DNA Demethylation -- 9.1 DNA Methylation: One Building Block of the Epigenome -- 9.2 DNA Methylation Reprogramming: Setting the Epigenome Up for Success -- 9.3 Active DNA Demethylation: The Hunt for the `Demethylase´ -- 9.4 Direct DNA Demethylation -- 9.5 Indirect Loss of DNA Methylation -- 9.5.1 Role of Cytosine Deamination in DNA Demethylation.
9.5.2 Methylcytosine Oxidation-Based Demethylation Mechanisms -- 9.6 Chromatin Remodelling, DNA Replication, and Repair: The Epigenetic Triumvirate -- 9.7 Replication-Coupled Loss of DNA Methylation: Passive Demethylation -- 9.8 Resetting and Erasure of the Germline: A Barrier Against Transgenerational Inheritance -- 9.8.1 Demethylation During Preimplantation Development -- 9.9 Removing the Molecular Escapement Mechanism to Cell Fate and Aging by Modulation of DNA Methylation: How Cells Can Turn Ba... -- References -- 10: Structure and Function of TET Enzymes -- 10.1 Introduction -- 10.2 Discovery of TET-Mediated 5mC Oxidation -- 10.2.1 TET-Mediated Iterative Oxidation of 5mC -- 10.2.2 TET-Dependent DNA Demethylation -- 10.2.3 Mechanisms and Processivity for TET-Mediated Oxidation Reaction -- 10.2.4 Oxidation of 5mrC-RNA and 6mA-DNA -- 10.3 Function of TET Enzymes -- 10.3.1 Distribution of TET Enzymes and 5mC Oxidation Derivatives -- 10.3.2 TET in ESCs and Cell Differentiation -- 10.3.3 TETs Mediate Epigenetic Reprogramming in Early Embryogenesis and PGC Development -- 10.3.4 TET Enzymes in Somatic Cell Reprogramming -- 10.3.5 TET Enzymes and Cancer -- 10.3.6 TET Enzymes in Neural System -- 10.4 Structure of TET Enzymes -- 10.4.1 Domain Structure of Human TET Enzymes -- 10.4.2 Crystal Structure of the TET2-5mC-DNA Complex -- 10.4.3 Crystal Structure of the NgTet1-5mC-DNA Complex -- 10.4.4 Structural Basis for Substrate Preference in TET-Mediated Oxidation -- 10.4.5 Crystal Structure of Algal TET Homologue CMD1 in Complex with VC and 5mC-DNA -- 10.5 Regulation of TET Enzymes -- 10.5.1 Inhibitors -- 10.5.2 Activators -- 10.5.3 Interacting Proteins -- 10.6 Concluding Remarks -- References -- 11: Proteins That Read DNA Methylation -- 11.1 Introduction -- 11.2 The Methyl-CpG-Binding Domain Family -- 11.2.1 MeCP2 -- 11.2.2 MBD1 -- 11.2.3 MBD2.
11.2.4 MBD3.
Record Nr. UNINA-9910629285803321
Cham, Switzerland : , : Springer, , [2022]
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DNA Methyltransferases - Role and Function [[electronic resource] /] / edited by Albert Jeltsch, Renata Z. Jurkowska
DNA Methyltransferases - Role and Function [[electronic resource] /] / edited by Albert Jeltsch, Renata Z. Jurkowska
Edizione [1st ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (VIII, 535 p. 61 illus., 57 illus. in color.)
Disciplina 572.86
Collana Advances in Experimental Medicine and Biology
Soggetto topico Cell biology
Gene expression
Cytogenetics
Cell Biology
Gene Expression
ISBN 3-319-43624-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Mechanisms and biological roles of DNA methylation and DNA methyltransferases – from past achievements to future challenges -- DNA and RNA pyrimidine nucleobase alkylation at the carbon-5 position -- Bacterial DNA methylation and methylomes -- Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases -- Enzymology of mammalian DNA methyltransferases -- Genetic studies on mammalian DNA methyltransferases -- The role of DNA methylation in cancer -- Structure and mechanism of plant DNA methyltransferases -- DNA methylation and gene regulation in honey bees: from genome-wide analyses to obligatory epi-alleles -- N6-methyladenine: a conserved and dynamic DNA mark -- Pathways of DNA demethylation -- Structure and function of TET enzymes -- Proteins that read DNA methylation -- DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications -- Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns -- DNA methyltransferase inhibitors – development and applications -- Rewriting DNA methylation signatures at will: the curable genome within reach? -- Engineering and directed evolution of DNA methyltransferases -- DNA labeling using DNA methyltransferases.
Record Nr. UNINA-9910150454903321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui