T Cell Regulation by the Environment

• Autore: Anne L. Astier
• Pubblicazione: Frontiers Media SA, 2015
• Descrizione fisica: 1 online resource (115 p.)
• Soggetto topico: Medicine and Nursing
• Soggetto non controllato: helminth; Metabolism; microbiome; regulatory T cells; T cells; Vitamin D
• Persona (resp. second.): David A. Hafler
• Sommario/riassunto: Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.
• Titolo autorizzato: T Cell Regulation by the Environment
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910136800303321
• Lo trovi qui: Univ. Federico II