01903nam 2200373z- 450 991013680030332120231214132847.0(CKB)3710000000631119(oapen)https://directory.doabooks.org/handle/20.500.12854/60449(EXLCZ)99371000000063111920202102d2015 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierT Cell Regulation by the EnvironmentFrontiers Media SA20151 electronic resource (115 p.)Frontiers Research Topics2-88919-733-6 Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.regulatory T cellsVitamin DhelminthT cellsMetabolismmicrobiomeAnne L. Astierauth1328825David A. HaflerauthBOOK9910136800303321T Cell Regulation by the Environment3039001UNINA