Cancer screening and genetics / / Christopher L. Wolfgang, MD, PhD

• Autore: Wolfgang Christopher L.
• Pubblicazione: Philadelphia, Pennsylvania : , : Elsevier, , 2015; ©2015
• Descrizione fisica: 1 online resource (244 p.)
• Disciplina: 616.994042
• Soggetto topico: Cancer - Genetic aspects; Cancer - Early detection
• Note generali: "October 2015."
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Cover image; Title page; Table of Contents; Copyright; Contributors; Consulting Editor; Editor; Authors; Forthcoming Issues; Forthcoming Issues; Recent Issues; Foreword: Cancer Screening and Genomics; Preface; Background; Cancer Genetics and Implications for Clinical Management; Key points; Introduction; Understanding the cancer genome landscape and translating advances for therapeutic gain; Driver versus passenger mutations; Mutational signatures in cancer; Rationale of genotype-guided medicine; Managing tumor heterogeneity and resistance to targeted therapy ; Advancing molecular phenotype-guided therapy in pancreatic cancerIndividualized therapy initiatives; Inherited susceptibility of cancer in the era of next-generation sequencing; Exceptional responders; Summary; The Triple-Code Model for Pancreatic Cancer; Key points; Cross talk between genetics and epigenetics as a promising paradigm in pancreatology; Mechanistic basis of epigenetics: the nucleosome; Marking the genome by methylation; Epigenetic regulation by noncoding RNAs; Shaping gene expression through nuclear architecture ; Epigenetics opens a new era for pancreatic cancer markers and novel therapeutic modalitiesSummary; Principles of Cancer Screening; Key points; Introduction; Performance characteristics of screening tests; Measures of screening benefit; Common biases in assessing the benefits of screening; Harms of screening; Cost-effectiveness and targeted screening; Current recommended cancer screening tests in North America; Screening and Early Detection: Specific Diseases; Lung Cancer Screening; Key points; Introduction; Risks and harms of lung cancer screening; Practice of lung cancer screening; Summary ; Colorectal Cancer ScreeningKey points; Introduction: extent of the disease; Screening techniques and options; Clinical outcomes; Complications and concerns; Summary; Breast Cancer Screening; Key points; Introduction; Screening techniques and options; Personalized breast cancer screening; Complications and concerns; Summary; Screening for Viral Hepatitis and Hepatocellular Cancer; Key points; Screening for hepatitis B virus infection; Screening for hepatitis C virus infection; Diagnosing other viral hepatitides; Screening for hepatocellular carcinoma ; When to obtain a liver biopsy to diagnose hepatocellular carcinomaProstate Cancer Screening and the Associated Controversy; Key points; Introduction; Screening techniques and options; Clinical outcomes; Complications and concerns; Summary; Screening for Pancreatic Cancer; Key points; Introduction; How early does pancreatic cancer have to be detected for cure?; Target lesions; Who is at risk of developing pancreatic cancer? Who should be screened?; How should suspected lesions be managed?; Screening and Early Detection of Gastric Cancer; Key points ; Gastric cancer epidemiology: mortality, incidence between east and west
• Titolo autorizzato: Cancer screening and genetics
• ISBN: 0-323-40107-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910137119603321
• Lo trovi qui: Univ. Federico II
• Serie: Surgical clinics of North America ; ; Volume 95, Number 5.