04411nam 2200529 450 991013711960332120230807212006.00-323-40107-4(CKB)3710000000776361(EBL)4620987(OCoLC)956278034(MiAaPQ)EBC4620987(EXLCZ)99371000000077636120160901h20152015 uy 0engur|n|---|||||rdacontentrdamediardacarrierCancer screening and genetics /Christopher L. Wolfgang, MD, PhDPhiladelphia, Pennsylvania :Elsevier,2015.©20151 online resource (244 p.)Surgical Clinics of North America,0039-6109 ;Volume 95, Number 5"October 2015."0-323-40106-6 Includes bibliographical references at the end of each chapters and index.Cover image; Title page; Table of Contents; Copyright; Contributors; Consulting Editor; Editor; Authors; Forthcoming Issues; Forthcoming Issues; Recent Issues; Foreword: Cancer Screening and Genomics; Preface; Background; Cancer Genetics and Implications for Clinical Management; Key points; Introduction; Understanding the cancer genome landscape and translating advances for therapeutic gain; Driver versus passenger mutations; Mutational signatures in cancer; Rationale of genotype-guided medicine; Managing tumor heterogeneity and resistance to targeted therapyAdvancing molecular phenotype-guided therapy in pancreatic cancerIndividualized therapy initiatives; Inherited susceptibility of cancer in the era of next-generation sequencing; Exceptional responders; Summary; The Triple-Code Model for Pancreatic Cancer; Key points; Cross talk between genetics and epigenetics as a promising paradigm in pancreatology; Mechanistic basis of epigenetics: the nucleosome; Marking the genome by methylation; Epigenetic regulation by noncoding RNAs; Shaping gene expression through nuclear architectureEpigenetics opens a new era for pancreatic cancer markers and novel therapeutic modalitiesSummary; Principles of Cancer Screening; Key points; Introduction; Performance characteristics of screening tests; Measures of screening benefit; Common biases in assessing the benefits of screening; Harms of screening; Cost-effectiveness and targeted screening; Current recommended cancer screening tests in North America; Screening and Early Detection: Specific Diseases; Lung Cancer Screening; Key points; Introduction; Risks and harms of lung cancer screening; Practice of lung cancer screening; SummaryColorectal Cancer ScreeningKey points; Introduction: extent of the disease; Screening techniques and options; Clinical outcomes; Complications and concerns; Summary; Breast Cancer Screening; Key points; Introduction; Screening techniques and options; Personalized breast cancer screening; Complications and concerns; Summary; Screening for Viral Hepatitis and Hepatocellular Cancer; Key points; Screening for hepatitis B virus infection; Screening for hepatitis C virus infection; Diagnosing other viral hepatitides; Screening for hepatocellular carcinomaWhen to obtain a liver biopsy to diagnose hepatocellular carcinomaProstate Cancer Screening and the Associated Controversy; Key points; Introduction; Screening techniques and options; Clinical outcomes; Complications and concerns; Summary; Screening for Pancreatic Cancer; Key points; Introduction; How early does pancreatic cancer have to be detected for cure?; Target lesions; Who is at risk of developing pancreatic cancer? Who should be screened?; How should suspected lesions be managed?; Screening and Early Detection of Gastric Cancer; Key pointsGastric cancer epidemiology: mortality, incidence between east and westSurgical clinics of North America ;Volume 95, Number 5.CancerGenetic aspectsCancerEarly detectionCancerGenetic aspects.CancerEarly detection.616.994042Wolfgang Christopher L.1376864MiAaPQMiAaPQMiAaPQBOOK9910137119603321Cancer screening and genetics3413105UNINA